The aim of this study was to investigate the changes in some biochemical and haematological parameters due to liver damage caused by parasites in sheep infected with Dicrocoelium dendriticum. The study was conducted on 10 healthy sheep and 60 sheep infected with D. dendriticum. After the blood was taken from the sheep brought to the slaughterhouse in Van Municipality, the liver and gall bladder were examined after the slaughter, and the blood of sheep infected with D. dendriticum was brought to the laboratory and examined for some haematological and biochemical parameters.As a result of the examination, some changes were observed in the biochemical and haematological parameters. In statistical analysis: Haematologically compared with the healthy group of sheep infected with D. dentriticum; WBC, Neu, Eo and Mon values were higher than the control group's values, while RBC, Hct, Hb and MCV values were lower and no significant change was found in the Lym level. Results of biochemical parameters of sheep infected with D. dentriticum according to statistical analysis; ALT, AST and GGT values were higher than of the health group sheep, while serum TP, Alb and glucose values were found than lower.As a result; WBC, Neu, Eo, Mon, ALT, AST and GGT levels in infected sheep due to dicrocoeliasis which cause important pathological disorders in liver that have functions such as synthesis, metabolism and detoxification in the organism were found to be significantly higher compared to the same values of the healthy group. It is predicted that these parameters may be useful in determining the degree and prognosis of liver damage and will shed light on the studies to be performed in this field.