Fascioliasis is an importantparasitic disease caused by the liver flukeFasciola gigantica in Malaysia. Theinfestation of liver fluke in ruminants;cattle, sheep, goats and buffaloes can resultin economic losses to the country mainlydue to the drop in livestock production,reduction in growth rate, condemnationof liver, reduction in draught power andhigh usage of anthelmintics. This paperdescribes a case of liver fluke infestationin a two year old male buffalo that waseventually slaughtered. The buffalowas reported to be emaciated and wasreared in an oil palm plantation for useas draught power in buffalo-drawn cartsloaded with oil palm bunches; alongwith 18 other buffaloes of various ages.Previously, there were two cases of buffalodeaths from the same herd. The organand faecal samples were sent to KuantanRegional Veterinary Laboratory (RVL)for diagnostic work up. The receivedsamples were then sent to parasitology,histopathology and bacteriology sectionsfor laboratory analysis and confirmationon the pathogens. The bacteriology resultshowed Escherichia coli isolated in allinternal organs. Presence of adult flukes(Fasciola gigantica) were observed inthe bile duct of the liver through grossexamination and also histopathologicalevaluation and supported by the positiveresult of Fasciola ova via sedimentationtest conducted from the faecal sample, thusjustifying the final diagnosis as severe liverfluke infestation leading to emaciation andsimultaneously having colibacillosis.

Nursing sickness, the largest single cause of mortality in adult female mink (Mustela vison), is an example of a metabolic disorder, which develops when the demands for lactation require extensive mobilization of body energy reserves. The condition is characterized by progressive weight loss, emaciation, and dehydration with high concentrations of glucose and insulin in the blood. Morbidity due to nursing sickness can be as high as 15% with mortality around 8%, but the incidence is known to vary from year to year. Stress has been shown to trigger the onset of the disease and old females and females with large litters are most often affected. Increasing demand for gluconeogenesis from amino acids due to heavy milk production may be a predisposing factor. Glucose metabolism is inextricably linked to that of protein and fats. In obesity (or lipodystrophy), the ability of adipose tissue to buffer the daily influx of nutrients is overwhelmed (or absent), interfering with insulin-mediated glucose disposal and leading to insulin resistance. Polyunsaturated fatty acids of the n-3 family play an important role in modulating insulin signalling and glucose uptake by peripheral tissue. The increasing demand on these fatty acids for milk fat synthesis towards late lactation may result in deficiency in the lactating female, thus impairing glucose disposal. It is suggested that the underlying cause of mink nursing sickness is the development of acquired insulin resistance with 3 contributing key elements: obesity (or lipodystrophy), n-3 fatty acid deficiency, and high protein oxidation rate. It is recommended that mink breeder females be kept in moderate body condition during fall and winter to avoid fattening or emaciation. A dietary n-3 fatty acid supplement during the lactation period may be beneficial for improved glycemic control. Lowering of dietary protein reduces (oxidative) stress and improves water balance in the nursing females and may, therefore, prevent the development and help in the management of nursing sickness. It is also surmised that other, thus far unexplained, metabolic disorders seen in male and female mink may be related to acquired insulin resistance.

  This study was conducted to report the pathological changes in tissues taken from ewes suffering from emaciation and cachexia with referring to the most implicated possible diseases causing them, since emaciation lead to cachexia were the most devastating causes of life followed by economic losses in ewes has been planned and made.This scientific work was designed to collection samples with and histopathological study which were carried out on tissues in twenty old weak ewes purchased from local market in Amara city south of  Iraq. Tissue samples included multiple pieces of livers, lungs, and intestine which have been used in histopathological work. Results showed changes in all tissues taken from all animals of  the study ranged from thickening of the alveolar septa with interstitial hemorrhage and hyperplasia of bronchial epithelium in the lungs to complete atrophy of the intestinal villi, mucosal denudation, and mild mucosal inflammation in small intestine and mild bridging fibrosis in the centrilobular area in the liver. Results indicated that autopsied ewes had liver lesions occurrence 75%, intestinal lesion 70%, and lung lesion 65%, in all animals of the study , however within the same animals results were indicated that liver and lung lesions 60% , liver and intestinal lesions 55%, lung and intestine lesions 55%, and liver, lung and intestine lesions50%. It had been concluded from this study that aged cachectic and emaciated ewes have a dramatic pathological changes in their internal vital organs and tissues and the possible causes of these changes are an underling debilitating chronic disease states that render the affected animals weak and unhealthy animals.