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Effects of diazepam on fetal development in rats
1999
Kim, C.J. | Kim, Y.J. | Yu, I.J. (Chonbuk National University, Chonju (Korea Republic). Department of Obstetrics, College of Veterinary Medicine)
To investigate the effect of diazepam on fetal development in pregnant rats, this experiment was performed in eighty Sprague-Dawley female rats which were 8 weeks old and grouped into two according to different diazepam treatment period during 5-9 days of gestation and 10-14 days of gestation. Both experimental groups were included by saline treated groups (control) and diazepam-treated groups (6mg, 12mg and 24mg), respectively. Diazepam was injected to pregnant rats subcutaneously, which were wacrified on 20 days of gestation and mean litter size, fetal body weight, fetal crown-rump length (CRL) and pathological findings were examined. 1. Concerning mean litter size, diazepam-treated groups showed lower mean litter size than control in both 5-9 days and 10-14 days of gestation groups(p0.05) without difference according to dosage of diazepam and day of gestation. 2. Concerning fetal body weight, diazepam-treated groups during 5-9 days of gestation showed lower fetal body weight than control and the other treated group during 10-14 days(p0.01) without difference according to dosage of diazepam. Diazepam-treated group during 10-14 days of gestation showed no difference among experimented groups. 3. Concerning fetal crown-rump length (CRL), diazepam-treated groups during 5-9 days of gestation showed shorter CRL than control and the other treated group during 10-14 days of gestation(p0.01) without difference according to dosage of diazepam. 4. Reduction of mean litter size, fetal body weight and CRL was shown from when treated by the dosage of 6mg/kg of diazepam. 5. Maternal mortality according to dosage of the 20mg/kg of diazepam were 30% and 20% in the treated group during 5-9 days and 10-14 days of gestation, respectively. These results indicated that diazepam treatment in pregnant rats caused considerable reduction of mean litter size, fetal body weight and fetal crown-rump length when treated during 5-9 days of gestation.
Afficher plus [+] Moins [-]Changes of plasma progesterone concentrations during the gestation and peripatum period, and return to estrus after parturition in Korean native goats
1992
Park, Y.J. | Kang, B.K. | Choi, H.S. | Park, B.J. | Son, C.H. (Chonnam Nat'l Univ., Kwangju (Korea Republic). Coll. of Veterinary Medicine)
The effects of selenium on fetal growth and development in CD-1 mice exposed with mercury for the gestation period
1994
Kim, J.S. | Lee, S.M. | Lee, W.C. (Konkuk University, Seoul (Korea Republic). Department of Veterinary Medicine) | Choi, S.W. (Chungbuk National University, Cheongju (Korea Republic). College of Veterinary Medicine)
Studies on intrauterine factors influencing implantation of embryo
1992
Lee, S.S. | Kwun, J.K. (Seoul Nat'l Univ., Suwon (Korea Republic). Coll. of Veterinary Medicine)
