Results of serological examinations of blood serum of sheep on revelation of virus respiratory infections (parainfluenza-3, adenovirus and respiratory syncytial) realized in the conditions of the Kyrgyz Republic were presented. Research results showed that in farm and peasant farm holdings of all studied districts of the Kyrgyz Republic of three types of pneumo viral infections simultaneously give high levels of antibody titers in relation to parainfluenza-3 – 1:128, adenovirus – 1:32, respiratory syncytial infection – 1:16. In some districts sheep population was diseased only by parainfluenzal infection in relation with titer of specific antibodies 1:256

Research results showed that in the conditions of correct organization and application of technological methods of livestock breeding and feeding it was possible to achieve high livability rate of sheep and lambs up to 90%. Also it was possible to get a substantial break of infection chain of many sheep diseases (especially those which had a respiratory nature). Research results showed that simultaneous application of convalescent-phase serum against sheep acute respiratory diseases, as well as Nitox 200 and Invamek for treatment of sheep and especially 2-3 month old lambs with respiratory infectious diseases promoted the recovery of 80-100% of animals.

After the pathomorphological and histological studies of innards of fallen experimental animals in all realized experiments it was found that sheep and lambs infected with pneumoviral infections (Parainfluenza-3, Adenoviridae, respiratory streptococcosis infection) with their additional infestation with radioactive substances there was stated the acceleration of infectious process, and disease recrudesced up to 2-5 and more times (depending on irradiation doze). The immunity of sheep and lambs decreased caused by reproduction of viruses, and in acute cases animals died but in cases of mild forms the disease transformed into chronic form and caused animal death.

For the well-timed prevention and treatment of sick animals there was analyzed the therapeutic efficiency of a produced survivor serum against acute respiratory diseases of sheep and lambs, as well as Catosal in combination with Nitox 200 against the mixed flow of parainfluenza-3, adenovirus, respiratory syncytial, chiamydial and pasteurellosis infection. Comparative efficiency of all mentioned preparations was presented. Research results showed the correct and timely application of drug preparations as well as their qualitative selection made it possible to lower the death cases. Application of the presented survivor serum in combination with Nitox 200 and Catosal made it possible to lower the loss of cattle in 4-5 times and increase the viability rate of animals