Pest des petits ruminants (PPR) and sheep pox (SP) viruses represent a hazard facing the sheep population. The present work dealt with the preparation of a combined live attenuated vaccine that protects sheep against the two diseases. Successfully, combined Peste des petits ruminants and sheep pox freeze-dried vaccine was proven to sterile and be free from different aerobic and anaerobic bacteria, fungi, and mycoplasma contaminants; safe (as no atypical reaction either local or systemic in mice and sheep and did not affect close contact unvaccinated sheep) and potent (providing vaccinated sheep with high protective specific immunity against both causative viruses) for 6 months (the experimental period) suggesting that such immunity will remain to not less than one year. It could be recommended the use of such a vaccine to control the two diseases using one shot of vaccination saves time, effort, and cost.Â