Results of serological examinations of blood serum of sheep on revelation of virus respiratory infections (parainfluenza-3, adenovirus and respiratory syncytial) realized in the conditions of the Kyrgyz Republic were presented. Research results showed that in farm and peasant farm holdings of all studied districts of the Kyrgyz Republic of three types of pneumo viral infections simultaneously give high levels of antibody titers in relation to parainfluenza-3 – 1:128, adenovirus – 1:32, respiratory syncytial infection – 1:16. In some districts sheep population was diseased only by parainfluenzal infection in relation with titer of specific antibodies 1:256

Studying of topical-product-induced irritation properties of pharmaceutical forms elecampane (Inula helenium) (herbal infusion, tincture, liquid and dry extracts) on skin integuments and conjunctiva of experimental animals (Guinea pigs (Cavia porcellus), rabbits (Oryctolagus), sheep and piglets). Research results showed that the preparative forms of elecampane had poorly expressed irritating properties after application on the skin of animals, as well as weak irritating action with the exception of the native forms of tincture and liquid extract of eye conjunctiva, that proved their total low toxic effect. Topical-product-induced irritation effect of herbal infusion (1:10), tincture and liquid extract in constitution (40 % concentration) and suspension of dry extract in strength of 10%, 15%, and 20% after the single application on skin could be referred to the I class – absence of irritating action. Topical-product-induced irritation effect of herbal infusion and liquid extract in native form (70% concentration) could be referred to the II class – light irritating action. Irritating activity of herbal infusion of eye conjunctiva was evaluated as light, as it was insignificant and short. Irritating action of suspended matter of dry extract in strength of 10%, 15%, and 20% was estimated as a limited one, which disappeared in 24 hours. Irritating action of tincture and liquid extract in constitution (40 % concentration) was evaluated as a high-grade one, which did not disappear in 24 hours. Irritating action of tincture and liquid extract in native form (70 % concentration) was evaluated as a pronounced one, which did not disappear for than 24 hours

Serological properties of leptospirae bacteria grown on differential nutritive media were studied by the example of sheep in the conditions of the Republic of Belarus. In the experiment there were used 6 pathogenic industrial leptospirae stock: Leptospira pomona VGNKI-6; Leptospira tarassovi VGNKI-4; Leptospira grippothyphosa VGNKI-1; Leptospira icterrohaemorragia VGNKI-2; Leptospira conicola VGNKI-3; Leptospira hardjo VGNKI-5. The results showed a serological difference of leptospirae grown on conventional and experimental media derived from ram's blood.

On the basis of analysis of literary sources and realized studies there was realized an evaluation of the degree of losses caused by ruminant monieziasis in the conditions of modern agricultural production in the Republic of Belarus; the strategy of medical and preventive measures was presented. In course of studies there were analyzed sheep and cattle of different classes bred in farm holding of Belarus and imported from abroad, as well as different anthelmintic agents. Studying of antihelminthefficiency was tested on lambs with body weight 20 kg. Lambs were infested with moniezia (Moniezia expansa). Analysis of anthelmintic agent Alverm efficiency was realized by the example on infested heifers. Albazen was administrated once in dose of 0,8 mg/1 kg. Prazikvantel was administrated once in dose of 5,0 mg/1kg. Alverm was administrated once in dose of 80,0 mg/1 kg. Research results showed 100% extencefficiency and intencefficiency of albazen and prazikvantel. Alverm administrated once in dose of 80,0 mg/1 kg gly had 100 % 100 % extencefficiency and intencefficiency

Research results showed that in the conditions of correct organization and application of technological methods of livestock breeding and feeding it was possible to achieve high livability rate of sheep and lambs up to 90%. Also it was possible to get a substantial break of infection chain of many sheep diseases (especially those which had a respiratory nature). Research results showed that simultaneous application of convalescent-phase serum against sheep acute respiratory diseases, as well as Nitox 200 and Invamek for treatment of sheep and especially 2-3 month old lambs with respiratory infectious diseases promoted the recovery of 80-100% of animals.

Investigation of histomorphological characteristics, organoleptic and physicochemical parameters of sheep meat and slaughter products, their biological value and bacterial number was realized in the conditions of the Republic of Belarus. Research results established that administration of liquid extract of common St.-John's wort (Hypericum perforatum) made it possible to obtain the substantial degree of sheep carcass bleeding, as well as the formation of a drying crust on a carcass surface. At a cut there was revealed the firm texture meat of light red or red color. Cut surface was wet and had specific flavour for the observed type of meat. Fat was solid, white or with yellow colour tone; tendons were elastic and solid. Analysis of boiled meat of sheep which were administrated by amber liquid essence showed that the cooking water was clear, without foreign odor. Meat of sheep, which were administrated by 2,5 % albazen suspension and were killed at 2 and 7 investigation days, had light medical odor in cooking water. In control variants the organoleptic parameters of sheep carcasses corresponded to fresh meat parameters of healthy animals. Realized physical-chemical analysis established the positive qualitative reaction to activity of peroxydase ferment in all meat samples, as well as the negative reaction to determination of primary protein breakdown products. Organoleptic and physical-chemical parameters of sheep meat after administration of amber liquid essence did not have any differences from animal meat of the control group

The dynamics of changes of nonspecific cellular-humoral immunity parameters of sheep in the conditions of in the conditions of oppression of parasympathetic part of autonomic nervous system was studied in the conditions of the Republic of Belarus. For the experimental animals there was applied atropine sulfate. Experiment was realized by an example of two groups (control and experimental) of yeld ewes. Blood was taken from jugular vein before administration of the preparation, and then in 1, 3, 6, 12, 24 hours, 1, 2, 3 days after the beginning of experiment. As a result of realized study there was stated a directly-proportional dependence in changes of phagocytes activity of leukocytes.

Data оn evaluations of therapeutic efficacy of albendazol and fenbendazol agaonst acute and chronic forms of larval cestodiasis of animals were studied in the conditions of the Republic of Belarus by an example of experimentally infested sheep and rabbits. Application of albendazol and fenbendazol both separately and in complex with antioxidant vitamin and mineral additive against the chronic forms of cysticercosis tenuicollis and cysticercosis pisiform was inefficient. But application of albendazol against acute form of cysticercoses caused the lowering of invasion intensity in shepp and rabbits in 3 times, fenbendazol – in 2,6 times. Application of anthelmintic agents in complex with vitamin and mineral composition promoted the lowering of invasion intensity (in 5 and 4,1 times, respectively) and prevented the disease development in 60% of animals.

Determination of interactions of monoinfestations and associations of parasites with the normal microflora of intestines of sheep was realized in the conditions of the Republic of Belarus. In the conditions of low associative infestations with Moniezia sp., Strongylata and Strongyloides nematodes, Eimeria protozoa there were stated changes in intestine microflora of sheep: sharp decrease of quantity of bifidus bacteria and lactic acid bacillus, colibacilli with the simultaneous presence of lactose-negative Bacillus coli, increasing number of aerobic bacteria. Recovery of monieziae in the conditions of presence in parasitocoenosis composition of nematodes of suborder Strongylata and Strongyloides species, Eimeria promoted the restoration of quality and quantity composition of microflora of sheep gastrointestinal tract

Problem of ruminant monieziasis is widely distributed in the Republic of Belarus. For the eradication of farm holdings and complexes there was proposed a complex of measures which included the application of highly efficient anthelmintic agents, including preparations for injection therapy and prolonged substances for intrajejunal administration (boluces).