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Effects of vitamin C on oxidative status in pigs anesthetized with isoflurane
2012
Lee, J.Y., Chungnam National University, Daejeon, Republic of Korea | Kim, M.C., Chungnam National University, Daejeon, Republic of Korea
This study investigated the effects of vitamin C on oxidative stress induced by volatile anesthetics in pigs. One group of pigs was used as an anesthesia control group (group 1), and they were anesthetized with isoflurane in oxygen and saline (0.9% NaCl) was injected intravenously. The other group (group 2) was anesthetized with isoflurane and injected intravenously with vitamin C. Total oxidant status, total antioxidant status, and the oxidative stress index in group 2 were significantly different compared with those in group 1. The results showed that intravenous administration of vitamin C decreased oxidative stress during isoflurane anesthesia in pigs.
Afficher plus [+] Moins [-]Oxidative Stress in C100 Cells Induced by Combined Treatment of Benzo(a)pyrene and/or 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)
Bae, M.O.;Choi, K.H.;Lee, H.J.;Kim, H.W.;Kim, J.S.;Hwang, S.K.;Park, J.H.;Cho, H.S.;Cho, M.H.(Seoul National University, Seoul, Republic of Korea)E-mail:mchotox@snu.ac.kr
When an organism is exposed to various toxicants chronically, reactive oxygen species(ROS) are accumulated and eventually result in several biological effects from gene expression to cell death. In the present study we investigated the oxidative damage of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) and/or benzo(a)pyrene (B(a)P) in C100 cells. C100 cells treated with TCDD(30 nM) and B(a)P(3 μM) underwent diverse oxidative stress as determined through thiobarbituric acid-reactive substances(TBARS) formation, DNA fragmentation, DNA single strand break(SSB) assay, immunohistochemical staining of 8-hydroxy-2'-deoxyguanosine(8-OHdG), and mRNA expressions of antioxidant enzymatic genes such as Cu/Zn-SOD gene, GPx(glutathione peroxidase 5) gene, and catalase gene.
Afficher plus [+] Moins [-]The relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in mesangial cells
Park, S.H.;Heo, J.S.;Han, H.J.(Chonnam National University, Gwangju, Republic of Korea)E-mail:hjhan@chonnam.ac.kr | Kang, C.W.(Chonbuk National University, Jeonju, Republic of Korea)
The proliferation of mesangial cells has been associated with the development of diabetic nephropathy. The cell proliferation has been regulated by diverse growth factors. Among them, insulin like growth factors(IGFs) are also involved in the pathogenesis of diabetic nephropathy. However, it is not yet known about the effect of high glucose on IGF-I and IGF-Ⅱ secretion and the relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in the mesangial cells.
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