Affiner votre recherche
Résultats 1-4 de 4
Effect of dietary protein on functional, morphologic, and histologic changes of the kidney during compensatory renal growth in dogs.
1991
White J.V. | Finco D.R. | Crowell W.A. | Brown S.A. | Hirakawa D.A.
Two diets similar in caloric density and mineral content, but markedly different in protein content, were used to study the effects of dietary protein on renal function and morphologic and histopathologic changes in dogs that had functional renal tissue reduced by seven-eighths nephrectomy. The effects of moderate protein intake (MPrI = 15% protein; dry-matter basis) and high-protein intake (HPrI = 31% protein; dry-matter basis) were studied for the initial 7 months (period 1 [P1]) after renal mass reduction. Diets were then switched between groups during the following 7 months (period 2 [P2]) to evaluate the effects of increased or decreased protein intake. The HPrI caused significantly (P < 0.05) greater glomerular filtration rate (GFR) and renal growth than did MPrI during P1. Dogs that maintained HPrI during P1 and MPrI during P2 (group 1) had significant (P < 0.05) reduction in GFR during P2. Dogs that maintained MPrI during P1 and HPrI during P2 (group 2) had significant (P < 0.05) improvement in GFR and renal growth during P2. At the end of the study, renal reserve was evaluated in both groups of dogs before and after group 1 was returned to HPrI for 2 weeks. During this 2-week feeding trial, group-1 dogs had marked improvement in renal reserve, relative to group 2, and GFR increased to the terminal P1 values. Results indicate a possible residual benefit from HPrI during the early phase of compensatory renal growth in the form of functional compensatory memory to HPrI. The severity of renal lesions was indistinguishable between dogs of dietary groups during both study phases. Plasma electrolyte concentrations rapidly returned to normal range after renal ablation, but mild azotemia and proteinuria persisted throughout most of the study. High protein intake was not associated with increased degree or progression of proteinuria.
Afficher plus [+] Moins [-]Pathophysiologic effects of Ostertagia ostertagi in calves and their prevention by strategic anthelmintic treatments.
1991
Xiao L. | Gibbs H.C. | Yang C.
Pathophysiologic effects of Ostertagia ostertagi infection and their prevention by strategic anthelmintic treatments were studied in 3 groups each of 6 steer calves. Group-1 calves were noninfected controls. Group-2 calves were inoculated with 100,000 third-stage larvae on the 1st and 28th days of the experiment and grazed on pasture initially free of contamination. Group-3 calves were on a similar regimen as those in group 2, but were also treated with ivermectin 9 days after each larval inoculation. Group-2 calves had increased plasma pepsinogen and gastrin values and decreased weight gains, and total serum protein and albumin concentrations from the 2nd week of infection onward. They were anemic at 10 to 12 weeks and had lower carcass and meat quality at slaughter. Strategic anthelmintic treatments were effective in preventing these effects and calves in groups 1 and 3 had similar performances. On the basis of our findings, high pepsinogen values were related to worm burdens, whereas high gastrin concentrations were related to gastric lesions.
Afficher plus [+] Moins [-]Histopathological studies on the influence of mast cell in the growth of rat mammary carcinoma, 2; Effect of mast cell mediator on the development of rat mammary carcinoma
1991
Kim, T.H. (Korea Atomic Energy Research Institute, Seoul (Korea Republic). Korea Cancer Center Hospital) | Lee, C.S. (Kyungpook National Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine)
Experimental trichothecene (T-2) Toxicosis in Guinea pigs
1991
Kim, J.S. (Gyeongsang National Univ., Chinju (Korea Republic). Coll. of Veterinary Medicine) | Park, U.B. (Seoul National Univ., Suwon (Korea Republic). Coll. of Veterinary Medicine)