Benzophenones (BPs) are used in various branches of industry as ultraviolet radiation filters, but they pollute the natural environment, penetrate living organisms, and disrupt endocrine balance. Knowledge of the exposure of domestic animals to these substances is extremely scant. The aim of the study was to investigate long-term exposure of companion dogs to BPs and relate this to environmental factors.

Cancerous tumors are one of the main problems that cause of deaths in pet animals. The objective of this paper is to describe histopathological features of some neoplastic masses with confirmation using immunohistochemistry in pet animals.  Our study was done from May 2022 to August 2023 in Sharkia governorate, Egypt to correctly recognize 7 cases of pet animal neoplasms "5 cases of dogs and 2 queen case" based on histopathological and immunohistochemical findings.  The results revealed 2 cases of TVT in Penis with positive expressions for Iba2 and vimentin  , 1 Case of Sebaceous adenoma in Hock joint of male dog skin, 1 case of hepatoid carcinoma in perianal glands of male dog with positive immunolabelling for CK7  , 1 case of chondroblastic osteosarcoma  in A 4-year old, male, Great Dane dog  and 2 cases of queen with mammary gland adenocarcinoma with positive immunoreactivity for HER-2 and other mixed mammary neoplasm accompanied with sarcoma has positive staining for vimentin. It could be concluded that  the histopathological evaluations by H&E stain is the backbone method for neoplasms diagnosis and  using some  biomarkers added a confirmatory tools for these diagnosis.