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An experimental model of chronic renal disease in dogs by infusion of microspheres into the renal arterial circulation.
1990
Dzanis D.A. | Krook L. | Harvey H.J. | Kallfelz F.A.
The feasibility of renal arterial infusion of nonbiodegradable microspheres as a model of chronic renal disease in dogs was evaluated. Resin-coated, styrene-divinyl benzene copolymer microspheres were infused into the kidneys of healthy adult Beagles by direct injections of both renal arteries in a single surgical procedure. Injections of 25-micrometer diameter microspheres had minimal effect on either the clinical status or serum values of the dogs. Histologic examination revealed the majority of the microspheres lodged within the capillary beds of the glomeruli, and little change to the kidneys. However, injections of 50-micrometer diameter microspheres caused significant increases in serum concentrations of urea nitrogen and creatinine. Histologically, the larger microspheres obstructed afferent arterioles and small arteries, which caused diffuse glomerular necrosis and nephron damage. With doses ranging from 1 to 3 million microspheres/dog, a correlation between the quantity of microspheres injected and severity of renal damage was observed. The optimal dose for producing a model of moderate renal disease was determined to be 1.8 million microspheres/dog (0.9 million microspheres/kidney). During long-term studies, microsphere-injected dogs fed a moderately restricted protein ration remained relatively azotemic, compared with control dogs on the identical ration. During the 5-month postsurgical period, the serum urea nitrogen concentration averaged 18.41 +/- 1.59 mg/dl (mean +/- SE) for the microsphere-injected dogs vs 9.31 +/-0.38 for the control dogs (P < 0.001). Similarly, the mean serum creatinine value was significantly higher (P = 0.020) for the microsphere-injected dogs, compared with the controls (1.23 +/- 0.12 mg/dl vs 0.94 +/- 0.03). In addition, the difference in mean endogenous creatinine clearance rates was statistically significant (microsphere-injected 1.02 0.05 ml/min/kg, vs control 1.53 +/- 0.06, P < 0.001).
Afficher plus [+] Moins [-]Fine structure of Theileria sergenti merozoite in Korean native cattle.
1990
Baek B.K. | Kim B.S. | Lee H.I.
Light microscopic observations on the in vitro effects of praziquantel on Heterophyopsis continua.
1990
Woo H.C. | Suh M.D. | Hong S.J.
Avidin-biotin complex for immunohistochemical diagnosis of Aujeszky's disease and hog cholera.
1990
Kim S.B. | Sur J.H. | Moon U.G.
Pathogenicity, hemagglutinability and the effect of physicochemical agents on virus of rabbit hemorrhagic disease.
1990
Yoon I.J. | Jeon Y.S.
Immunohistochemical identification of Newcastle disease virus with indirect immunoperoxidase technique.
1990
Nho W.G. | Sur J.H. | Kim S.B.
Studies on the early diagnosis of pregnancy of dairy cows by EIA-kit of progesterone in milk.
1990
Kim M.K. | Shin H.J. | Lee M.H. | Lee M.H. | Kim S.K.
Effects of ammonia water on sporulation of coccidial oocysts originated from bovine.
1990
Wee S.H. | Kang Y.B. | Jang H. | Lee H.S. | Choi S.H.
Antagonism of xylazine-induced hypotensive effect by yohimbine in rabbits.
1990
Shin D.H.
Cultivo de Spirulina maxima ao ar livre. 1: inverno.
1990
Ruiz R.L. | Mos E.N. | Lima C.G. de | Ribeiro M.A.M.
