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Study on the expression of testin in the testes of dogs
2023
Ciaputa Rafał | Nowak Marcin | Dzimira Stanisław | Brambilla Eleonora | Kandefer-Gola Małgorzata | Tomaszek Alicja | Popiel-Kopaczyk Aneta | Dzięgiel Piotr | Grieco Valeria
Testin is a protein involved in cell mobility, adhesion and colony formation. In rats, testin presence has been reported in the testes, and its possible role in spermatogenesis has been suggested. Studies in humans also suggest a possible role of testin as a cancer suppressor protein. In the dog, which represents both an important pet species and a good animal model for studying biological and pathological testicular processes, the presence of testin has never been reported.
Afficher plus [+] Moins [-]Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system
2023
Bulak Kamila | Kycko Anna | Śmiech Anna | Łopuszyński Wojciech
Mast cell tumours (MCTs) arise in the dermis and subcutaneous tissues in animals and humans and are one of the most common neoplasms of the skin in dogs. Cannabinoid type 2 receptor (CB2R), cyclin-dependent kinase inhibitor (p21) and matrix metalloproteinase 1 (MMP-1) are potential targets for novel anti-tumour therapeutic strategies. This study evaluated by immunohistochemical means the reactivity of p21, MMP-1 and CB2R proteins in association with a three-tier grading system in cutaneous canine MCTs.
Afficher plus [+] Moins [-]The serological and genetic diversity of the Leptospira interrogans Icterohaemorrhagiae serogroup circulating in the UK
2023
Arent Zbigniew | Gilmore Colm | Pardyak Laura | Dubniewicz Klaudia | McInerney Barry | Ellis William
Strains of Leptospira interrogans belonging to two very closely related serovars, Icterohaemorrhagiae and Copenhageni, have been associated with disease in mammalian species and are the most frequently reported agents of human leptospirosis. They are considered the most pathogenic serovars and represent more than half of the leptospires encountered in severe human infections.
Afficher plus [+] Moins [-]Echinococcus multilocularis genetic diversity based on isolates from pigs confirmed the characteristic haplotype distribution and the presence of the Asian-like haplotype in Central Europe
2023
Karamon Jacek | Samorek-Pieróg Małgorzata | Bilska-Zając Ewa | Korpysa-Dzirba Weronika | Sroka Jacek | Bełcik Aneta | Zdybel Jolanta | Cencek Tomasz
The aim of the study was to determine the genetic diversity of Echinococcus multilocularis in pigs in highly endemic areas in Poland, as well as to attempt to confirm the occurrence and geographical distribution of haplotypes characteristic for these areas, which were previously described on the basis of examination of adult tapeworms isolated from foxes.
Afficher plus [+] Moins [-]Enterovirus E infects bovine peripheral blood mononuclear cells. Implications for pathogenesis?
2023
Małaczewska Joanna | Wróbel Małgorzata | Kaczorek-Łukowska Edyta | Rękawek Wojciech
Enterovirus E (EV-E) is a common viral pathogen endemic in cattle worldwide. Little is known, however, about its potential interactions with bovine immune cells.
Afficher plus [+] Moins [-]Development, in-house validation and application of a method using high-performance liquid chromatography with fluorescence detection (HPLC-FLD) for the quantification of 12 ergot alkaloids in compound feeds
2023
Kowalczyk Ewelina | Kwiatek Krzysztof
Ergot alkaloids (EAs) are toxic substances naturally produced by Claviceps fungi. These fungi infest a wide range of cereals and grasses. When domestic animals are exposed to EAs through contaminated feeds, it is detrimental to them and leads to significant economic losses. For that reason, it is important to monitor feed for the presence of EAs, especially with methods enabling their determination in processed materials.
Afficher plus [+] Moins [-]The genetic variability of small-ruminant lentiviruses and its impact on tropism, the development of diagnostic tests and vaccines and the effectiveness of control programmes
2023
Olech Monika
Maedi-visna virus and caprine arthritis encephalitis virus are two closely related lentiviruses which cause multisystemic, progressive and persistent infection in goats and sheep. Because these viruses frequently cross the species barrier, they are considered to be one genetic group called small-ruminant lentiviruses (SRLV). They have in vivo tropism mainly for monocytes and macrophages and organ tropism with unknown mechanisms. Typical clinical signs are pneumonia in sheep, arthritis in goats, and mastitis in both species. Infection with SRLV cannot currently be treated or prevented, and control programmes are the only approaches to avoiding its spread. These programmes rely mainly on annual serological testing and elimination of positive animals. However, the high genetic and antigenic variability of SRLV complicate their early and definitive diagnosis. The objective of this review is to summarise the current knowledge of SRLV genetic variation and its implications for tropism, the development of diagnostic tests and vaccines and the effectiveness of control and eradication programmes.
Afficher plus [+] Moins [-]The use of plant extracts and bacteriophages as an alternative therapy approach in combatting bacterial infections: the study of lytic phages and Stevia rebaudiana
2023
Stachurska Xymena | Mizielińska Małgorzata | Ordon Magdalena | Nawrotek Paweł
In the light of the problem of antibiotic resistance, the use of combined alternative therapies in combatting bacteria-related disorders has gained popularity. Bacteriophages are one element implemented in new combination therapy. Stevia rebaudiana is known to have antimicrobial activity and regarded as potentially having a synergistic effect with bacteriophages. Therefore, possible interactions of lytic bacteriophages (MS2, T4 and Phi6) with acetone and methanol S. rebaudiana extracts (SRa and SRm) in the bacterial environment were examined.
Afficher plus [+] Moins [-]Multidrug resistance in Haemonchus contortus in sheep - can it be overcome?
2023
Babják Michal | Königová Alžbeta | Komáromyová Michaela | Kuzmina Tetiana | Nosal Pawel | Várady Marián
Gastrointestinal nematodes pose a threat to animal health and affect farmers by negatively impacting farm management.
Afficher plus [+] Moins [-]Why does Listeria monocytogenes survive in food and food-production environments?
2023
Osek Jacek | Wieczorek Kinga
Listeria monocytogenes is one of the most dangerous food-borne pathogens and is responsible for human listeriosis, a severe disease with a high mortality rate, especially among the elderly, pregnant women and newborns. Therefore, this bacterium has an important impact on food safety and public health. It is able to survive and even grow in a temperature range from -0.4°C to 45°C, a broad pH range from 4.6 to 9.5 and at a relatively low water activity (aW < 0.90), and tolerates salt content up to 20%. It is also resistant to ultraviolet light, biocides and heavy metals and forms biofilm structures on a variety of surfaces in food-production environments. These features make it difficult to remove and allow it to persist for a long time, increasing the risk of contamination of food-production facilities and ultimately of food. In the present review, the key mechanisms of the pathogen’s survival and stress adaptation have been presented. This information may grant better understanding of bacterial adaptation to food environmental conditions.
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