Determination of chronic toxicity of a new selenium-containing preparation Aesel was realized in the conditions of the Republic of Belarus. There was realized endermatic administration of the experimental preparation to laboratory white mice. Studying of sensitivity of some organs and systems of mice and revelation of a degree of reversibility of processes caused by active substances of the drug was realized. The main clinical, pathomorphologic, biochemical, hematological changes in the organism of laboratory animals with induced chronic toxicity were determined.

Evaluation of efficiency of chelate forms of trace elements in rations of pregnant sows as a factor of improvement of their production indices and quality of obtained litter. It was determined that introduction into pregnant sows rations of chelate forms of zinc and iron starting from the 84th day of pregnancy and till farrowing led to authentic increasing of milk yield, weight of a litter at birth and at weaning periods, to increasing of live weight of obtained litter, and also proved to be a form of hypothrophics prevention in piglets.

A method of development of highly purified antigen of a virus of classical swine fever (Sinlak strain) for definition of antibodies in enzyme multiplied immunoassay (ELISA) was tested in the conditions of the Republic of Belarus. There were determined parameters of sensitivity and specificity. There was developed a method of partial purification of the antigens by means of obtaining of infected leukoconcentrate, settling of virus by means of ammonium sulfate with the further ultrafiltration through a membrane

In the conditions of the Republic of Belarus after fasciolosis invasion of cattle for the biochemical diagnostics of liver pathologies there was composed a hepatospecific metabolic profile of blood serum of cattle into which there were included several enzymes (alanine aminotransferase; aspartate aminotransferase; gamma-glutamyl transpeptidase; alkaline phosphatase; and cholinesterase), content of total albumin, serum albumin, total cholesterin and total bilirubin, as well as colloid tests (thymol turbidity test and test for apoliproteins). There was revealed a intrahepatic cholestasis developed during fasciolosis infestation, as well as dysproteinemia as a compensatory mechanism of liver proteinsyntetic function.

Results of studying the local of irritating properties of preparative forms of marsh cinquefoil (Comarum palustre) which were intended for treatment of parasitic of diseases of animals, namely, strongylatosis of gastro-intestinal tract of sheep and calves realized in the conditions of the Republic of Belarus were presented. Preparative forms of Comarum palustre (liquor, tincture, liquid extract and powder) had poorly expressed irritating properties after application into skin of animals and weak irritating action, excluding native forms of tincture and liquid extract on mucous coat eye, that confirms their low toxicity action as a whole on organism of animals.

Morphological and structural changes in bone marrow of piglets which were immunized with produced in the Republic of Belarus SPS vaccine (against salmonellosis (Salmonella), pasteurellosis (Pasteurella) and streptococcus) in combination with immunostimulants and without them were analyzed in the conditions of the Republic of Belarus. Piglets of the first group were vaccinated against salmonellosis, pasteurellosis and streptoccocusis by SPS vaccine. Piglets of the second group were vaccinated by SPS vaccine with vitamin C. Piglets of the third group were vaccinated by SPS vaccine with immunotstimulant sodium thiosulphate. The fourth (control) group of animals was administrated with normal saline. Animals were immunized twice, intramuscularly with 7 day interval in dose of 4 ml (primary), and 5 ml (secondary). Vitamin С was administrated in dose of 0,05g per head. Sodium thiosulfate was administrated in combination with the vaccine in 30% concentration. Alongside with myelogram there were derived formulas of different cell groups of bone marrow: leucoerythroblastic index; intramedullary index of neutrophil maturity; intramedullary index of eosinophile maturity. Detailed myelogram of piglets on the 14-th day after the second immunization was presented. Research results showed that in all groups of vaccinated animals there was noted the activation of myeloblastic hematogenesis and decreasing of erythropoeisis. Piglet immunization was accompanied by strengthening of myeloblastic hematogenesis, increased number of lymphocytes and plasma cells in bone marrow

Comparison of morphological changes in placenta in the conditions of physiological pregnancy and pregnancy complicated acute asphyxia in farrow with deadborn piglets was realized in the conditions of the Republic of Belarus. There were realized complex clinical and morphological studies of placenta of pregnant sows. The experimental group was formed by pegnant sows with intranatally dead fetus because of acute asphyxia in course of farrowing caused by abnormality in placental circulation(prolapse of funis or loop of cord). The second (control) group consisted of healthy bred sows with physiological farrowing and alive newborn piglets. The groups were comparable to age, number of farrowings (no more two) and housing conditions. Detailed macrographic examinations of placenta (form, size, square, weight, volume, fetus-plecentary coefficient, amnion status and so on) and cord were realized. The research result showed that in the conditions of a complicated pregnancy in the thickness index placenta there were visualized a lot of connective tissue changed locus, infarcts as well as areas, and changes in morphometric indexes. All mentioned above factors proved to be a morphological substrate of fetoplacental insufficiency, which subsequently caused asphyxia, hypoxia, small-for-gestational-age fetus, and dead birth

Development of a new national preparation for the preventive maintenance of cow mastitis, fissures of milking tubes skin of cow udder was realized in the conditions of the Republic of Belarus. The preparation Maz' Solnechnaya ("Unguent Solnechnaya") did not contain antibiotics, hormones and other synthetic components. Natural components of a preparation provide long anti-inflammatory action, stimulate local blood circulation, regeneration of epidermis and accelerate processes of healing of microtraumas. Besides it possesses high efficiency at preventive maintenance of mastitises at cows.

Application of antiviral preparation Mixoferon for poultry is studied. It is established, that Mixoferon application does not influence negatively on organism of hens, increases intensivity of protein metabolism, including the maintenance of antibodies in blood whey. Mixoferon in dozes of 2,5 ml (500000 МЕ), 1,5 ml (300000 МЕ), 0,5 ml (100000 МЕ) can be used for preventive maintenance and therapy of virus infections of hens

Application zoned bare-grained oats grades in a diet of chickens and hens-layers of egg breeds makes positive impact on efficiency of a bird, forage conversion, reduces expenses of forages for manufacture of eggs that allows to receive additional profit. The maximum norm – 40 % bare-grained oats in mixed fodders of hens is defined