Water and sediment samples have been collected from five different stations, located along Djendjen River between February and June, 2016 so that the concentrations of Cd, Ni, Zn, and Cu could be determined. The extent of the sediment pollution has been assessed, using the multiple pollution indices, namely Contamination Factor (CF), Pollution Load Index (PLI), and the geoaccumulation index (Igeo).The distribution of trace elements in water and sediment follows Ni>Zn>Cd>Cu and Zn>Ni>Cu>Cd, respectively. The water sample analysis from Djendjen River shows that the total concentrations of Cu, Ni, Cd, and Zn have been lower according to the references. In comparison, sediment mean metal concentrations with several environmental contamination parameters, like probable effect level (PEC) and background levels, indicates that the concentrations of all investigated elements are lesser than PEC, except for Ni, but higher than the background levels. The Igeo values reveal that Cd has been the most accumulated compared to the other metals.  Contamination Factor (CF) confirms that the sediment samples have been moderate in terms of all studied metals contamination. The Pollution Load Index (PLI) values have been above one (>1), indicating an advanced decline of the sediment quality.