This study aimed to investigate the underlying anthropogenic driving factors of forest landscape degradation in the Kilimanjaro World Heritage Sites (WHS), Tanzania using survey-based data. The essence is to support strategic policies for forest landscape protection and natural heritage sustainability. The research employed empirical data using mixed questionnaires of experts and residents to identify various indirect anthropogenic driving factors of forest degradation, analyze rural poverty and causal mechanisms as indirect anthropogenic drivers of forest degradation, and evaluate the level of awareness and community involvement in forest protection. ArcGIS was used to generate the Maps. About 140 sample sizes were utilized for this study. Using purposive and simple random techniques, about 46 and 100 mixed questionnaires were distributed to experts in forest guard and residents, respectively. Data were analyzed using quantitative and qualitative techniques. Findings showed that indirect factors of forest degradation include high tourism demand, poverty, culture and tradition of local communities, lack of forest protection and conservation education, and insufficient land availability. Also, findings showed that rural poverty as an indirect anthropogenic driving factor of forest degradation is attributed to unemployment in rural areas, inadequate land for agriculture, and insufficient productive forestry availability. Additionally, this study revealed that residents are aware that the forest is under the government’s protection, and most people in local communities are not involved in activities for forest protection. Therefore, the study suggests that the locals should be involved in the activities that promote forest protection for effective control and management. Alternative heating methods should also be explored to reduce much pressure on the available forest to improve the natural heritage sustainability of natural WHS found in Sub-Saharan Africa and other parts of the Global South.