Water is essential for all living organisms in the universe. Chemicals can cause contamination in groundwater near aquacultural activity areas. Keeping in view the hectic aquacultural activity in surrounding locations of Akividu town in West Godavari District of AP, India, it is proposed to assess the chemical and microbial contamination of waters to suggest remedial measures to protect the quality of water for safeguarding the health of the public residing in the nearby habitations who consume these waters for drinking purposes. 16 Groundwater samples were collected and analyzed for assessing the physicochemical parameters viz., pH, Electrical conductivity (EC), Total Dissolved solids (TDS), Total hardness (TH), Total Alkalinity (TA), Na+, K+, Calcium, Magnesium, Chloride, Sulphate, Nitrate and Phosphate, Irrigation parameters like %Na, SAR, KR RSC, and microbial analysis. The study results revealed that the samples were contaminated chemically and also with pathogenic bacteria like Pseudomonas, Citrobacter freundii and Escherichia coli which can cause water-borne diseases. Further, a health survey was carried out to verify the adverse effects to be caused by the chemical and microbial contamination of water on people?s health. The health survey results indicated the sufferings of the people who consume this water for drinking and domestic purposes. The waters are to be treated accordingly to control the chemical and bacterial contamination by using the available treatment methodologies before considering them for drinking purposes.