Cadmium is one of the most carcinogenic and hazardous heavy metals on the earth for causes many serious diseases and disorders in the plant body. The presence of Cd in the soil is equally harmful to the production of rice crops and human beings. A pot experiment was conducted to analyze the consequences of cadmium-induced stress on the antioxidative defense system in rice plants. The assessment of antioxidative defense mechanism based on the cadmium-induced stress in the range of 100 to 300 ppm while the parameters, Chlorophyll Content Index (SPAD), nitrogen (%), relative water content (%), membrane stability index (%), proline content (μg.g-1), and catalase activity (nm H2O2 mg-1.min-1) were used. The highest reduction in the Chlorophyll Content Index (CCI), nitrogen (%), RWC (%), and MSI (%) was recorded at the highest concentrations of Cd Cl2 (300 ppm). However, at the same time, an increase in proline content (μg.g-1) and catalase activity (nm H2O2 mg-1.min-1) were also detected at all the intervals of the study. The activity of CCI, amino acid, and enzyme were presented in % increase/decrease over the control of Cd-induced stress in rice plants. The reduction (%) in CCI (SPAD) and RWC (%) was recorded maximum at 75 Days after transplanting (DAT), while nitrogen (%) and MSI (%) were recorded at 50 DAT. However, the increase (%) in proline and Catalase activity was maximum at 75 and 50 DAT.