Congenital heart defects (CHDs) are one of the major causes of death in infants and young children, and heavy metal exposure during pregnancy is one of the possible risk factors. However, the effect of heavy metal exposure on CHDs is still controversial. We searched English (PubMed, Web of Science) and Chinese (CNKI and WanFang database) databases for relevant articles. The summarized effect sizes and 95% confidence intervals (CIs) were calculated by pooling estimates using the random-effects model. Egger’s test was used to estimate publication bias. Heterogeneity among studies was indicated by p-values and I². Finally, we conducted subgroup analyses to elucidate the causes of heterogeneity. Thirteen studies were included in this meta-analysis. A positive association between maternal exposure to heavy metals and CHDs was found. Pooling odds ratios (ORs) for arsenic, cadmium, mercury, and lead were 2.12, 1.30, 1.22, and 2.30, respectively for total CHDs. Regarding CHD subtypes, arsenic was associated with an increased risk of septal defects (OR: 1.82), barium with left ventricular outflow tract obstruction (LVOTO) (OR: 1.15) and septal defects (OR: 1.21), and lead with conotruncal defects (OR: 2.34) and LVOTO (OR: 1.93). A heterogeneous relationship was found between studies using different methods of measurement, which were mainly due to differences in actual exposure levels to heavy metals. This meta-analysis suggests significant associations between arsenic, cadmium, mercury, and lead exposure during pregnancy and an increased risk of specific CHDs in offspring. These findings underscore the importance of heavy metal exposure during pregnancy in the risk of CHDs in offspring.

Ochratoxin A (OTA) is one of the most dangerous and that pollute agricultural products, inducing a variety of toxic effects in humans and animals. The current study explored the protective effect of different concentrations of Aspergillus awamori (A. awamori) against OTA (0.3 mg/kg diet) induced renal and cardiac damage by exploring its mechanism of action in 60 New Zealand white male rabbits. Dietary supplementation of A. awamori at the selected doses of 50, 100, and 150 mg/kg diet, respectively, for 2 months significantly improved the rabbit’s growth performance; modulated the suppressed immune response and restored the altered hematological parameters; reduced the elevated levels of renal injury biomarkers such as urea, creatinine, and alkaline phosphatase; and increased serum total proteins concentrations. Moreover, it also declined enzymatic activities of cardiac injury biomarkers, including AST, LDH, and CK-MB. A. awamori alleviated OTA-induced degenerative and necrotic changes in the kidney and heart of rabbits. Interestingly, A. awamori upregulated Nrf2/OH-1 signaling pathway. Therefore enhanced TAC, CAT, and SOD enzyme activities and reduced OTA-induced oxidative and nitrosative stress by declining iNOS gene expression and consequently lowered MDA and NO levels. In addition to attenuating renal and cardiac inflammation via reducing IL-1β, TNF-α gene expressions in a dose-dependent response. In conclusion,this is the first report to pinpoint that dietary incorporation of A. awamori counteracted OTA-induced renal and cardiac damage by potentiating the rabbit’s antioxidant defense system through its potent antioxidant, free radical scavenging, and anti-inflammatory properties in a dose-dependent response. Based on our observations, A. awamori could be utilized as a natural protective agent against ochratoxicosis in rabbits.

Maianthemum bifolium (L.) F. W. Schmidt is a clonal plant with a wide geographical range throughout Europe and Asia. It is also abundant as an understory plant of acid beech forests in southern Poland. The response strategies of this species to heavy metals and their effects on some functional traits (height, specific leaf area (SLA), leaf dry matter content (LDMC), specific rhizome length (SRL) and rhizomes dry matter content (RDMC)) were tested. Selected heavy metal concentrations were measured in leaves, rhizomes and rooting soil of May lily in five beech forests of southern Poland, mainly including an industrialised region of Upper Silesia. The contamination level of these ecosystems was assessed with a single pollution index. The results show significant contamination with Pb even at control sites and moderate with Cd, Zn, Fe and Cu in Upper Silesian forests. May lily accumulated Pb, Zn and Fe mainly in rhizomes, but Ni, Cu and Cd were also translocated to aboveground organs in comparable quantities, which confirms the indicator value of this plant. May lily accumulated up to 21 and 30 mg g⁻¹ Cd, 34 and 90 mg g⁻¹ Pb and 250 and 553 mg g⁻¹ Zn in leaves and rhizomes respectively. Moreover, the accumulation factors show that May lily accumulates Cd in above- and underground organs in higher amounts than found in soil. Although high concentrations of these toxic elements in tissues, no visible damages on plants were observed, also the measured functional traits show no apparent relationship with the pollution level.

Microplastics cause extensive contamination of water environments worldwide. As such, microplastics in freshwater systems have received increased attention in recent years. However, the effects of microplastics on freshwater macrophytes remain poorly understood. This study investigates the effects of microplastics on the submerged freshwater macrophyte Egeria densa. A laboratory experiment with controlled light, temperature, and nutrient conditions was conducted to explore the effects of exposure to low-concentration microplastics on the elongation, pigmentation, oxidative stress, antioxidant responses, and chlorophyll fluorescence parameters of E. densa. E. densa, planted soilless in aquaria, were exposed to 0.05, 0.25, 1.25, and 6 mg L⁻¹ of 3-µm polystyrene microspheres for 7 days. Changes in pigmentation, oxidative stress, antioxidants, and chlorophyll fluorescence parameters were observed even after exposure to the lowest concentration of microplastics. None of these responses correlated with increasing microplastic concentration. Elongation and photosynthetic pigments did not change significantly. Microscopic observations confirmed that the microplastic particles were not absorbed into tissues but were adsorbed to the roots. The microplastic concentration of 0.25 mg L⁻¹ was the threshold concentration value for E. densa. Our findings highlight the significant effects of microplastic on freshwater macrophytes. Further research is required to investigate the long-term responses to microplastic exposure.

This research aims to investigate the effect of foreign direct investment on carbon emissions through the panel ARDL method using annual data for the 1990–2016 period for the newly industrialized countries (NICs), including China, Malaysia, Mexico, Philippines, Thailand, Turkey, India, and Brazil. The stationarity of the series was obtained through LLC, IPS, and Fisher ADF panel unit root tests, the cointegration relationship with the panel ARDL-PMG approach, and the causality relationship with Dumitrescu and Hurlin (DH) tests. As a result of the long-term analysis, the foreign direct investment, energy consumption, and trade openness have a positive and significant impact on carbon emissions, whereas economic growth has a negative and significant impact on carbon emissions. The result shows that a percent increase in foreign direct investment increases carbon emissions by 0.03%. As a result of the short-term analysis, it was seen that the coefficient of the error correction term (ECT) was negative and statistically significant. According to DH panel causality test results, there exists a bidirectional causality relationship among energy consumption and carbon emissions, and a unidirectional causality relationship from economic growth and trade openness to carbon emissions and from carbon emissions to foreign direct investment. As policy implication, in industrialized countries especially China and India, there is a greater need to invest in green energy consumption at a larger scale to achieve future sustainable development goals.

Pluronics, due to its high water-soluble and thermoreversible ability, attracted much in biomedical applications. They are mainly utilized in drug delivery, gene therapy, and tissue remodeling. The study aims to explore the cytocompatibility of Pluronics F-127, which has gained much popularity due to its various properties. The cells were exposed to varying concentrations of Pluronics F-127 in A549 cells for 24 h. According to the MTT and neutral red assay, A549 cells displayed dose-dependent cell viability. The cell’s morphology was preserved after treatment, as seen in phase-contrast and Giemsa staining. When exposed to PF-127, lysosomal, cytoskeletal, and nuclear integrity were maintained. The percentage of live cells in all the treated groups was more significant than 90%, according to the live/dead flow cytometric analyses. The study identified the cytocompatibility of Pluronics F-127 required for the breakthrough in biomedical applications.

The study reported here concerns the geochemical distributions of macro- and trace elements (including potentially toxic elements, PTEs) in the vineyard soils of Alcubillas, which is one of the oldest, albeit not world-renowned, wine-growing areas in La Mancha (Central Spain). Soil and leaf samples were analyzed by X-ray fluorescence spectrometry to ascertain the levels of various elements in the soil and the plant. The potential toxicity of the elements was assessed with regard to the development of the vineyard. Despite the fact that fertilizers and pesticides are employed in the vineyards in this area, the results showed that the levels of trace elements in the soil samples did not exceed the reference values according the pedogeochemical values for the region and Spain. This finding suggests that the study area is not polluted, and therefore, there are hardly any traces of anthropogenic contamination. The Biological Absorption Coefficient (BAC) was calculated to assess the assimilation of various elements from the soil to the leaves, and differences were found in the element absorption capacity of the vines. Some elements were not taken up by Vitis vinifera despite elements like Zr and Rb being present in relatively high concentrations in the soil. The production in these soils does not represent a threat to human health or the ecosystem, because the farmers in this area are extremely careful to preserve the environment and they only farm to achieve moderate yields of grapes per hectare.

Present transport system of conventional vehicle in India has faced challenges due to enormous amount of air pollution, health hazards to human, rising oil price, insufficient indigenous fossil fuel reserve, heavy expenditure on oil import, energy insecurity, etc. Electrical vehicle (EV) is considered to be alternatives of conventional vehicles that can overcome these shortcomings. The aim of the study is to get an overview of the electric vehicle policies of government of India and its state governments to find out their relevance and impact on EV adoption in India. Exploratory research is used in present case to carry out the study. Currently, the EV industry in India is in preliminary condition and in growing stage. Government of India has framed policies such as “NEMMP 2020,” “FAME-I,” “FAME-II,” and Vehicle Scrappage policy. Seventeen of its state governments have framed EV policy. These policies facilitated various types of incentives, infrastructure development, fund allocation, research and development, production, and sales. This will have strong impact on EV demand generation, conversion of conventional vehicles to e-vehicle resulting E-mobility transformation and EV hub in the region that is at par with other EV-developed countries in the world. However, lack of policy and technology availability in the domain of disposal and reprocessing of Li-ion battery is found to be a future limitation of EV prospect in Indian context which needs to be looked into.

The present study attempted to investigate the changes in temperature conducive to fish habitability during the summer months in a hydrologically modified wetland following damming over a river. Satellite image–driven temperature and depth data calibrated with field data were used to analyse fish habitability and the presence of thermally optimum habitable zones in some fishes, such as labeo rohita, cirrhinus mrigala, tilapia fish, small shrimp, and catfish. The study was conducted both at the water’s surface and at the optimum depth of survival. It is very obvious from the analysis that a larger part of the wetland has become an area that destroyed aquatic habitat during the post-dam period, and existing wetlands have suffered significant shallowing of water depth. This has resulted in a shrinking of the thermally optimum area of fish survival in relation to surface water temperature (from 100.09 to 74.24 km² before the dam to 93.97 to 0 km² after the dam) and an improvement in the optimum habitable condition in the comfortable depth niche of survival. In the post-dam period, it increased from 75.49 to 99.76%. Since the damming effect causes a 30.53 to 100% depletion of the optimum depth niche, improving the thermal environment has no effect on fish habitability. More water must be released from dams for restoration. Image-driven depth and temperature data calibrated with field information has been successfully applied in data sparse conditions, and it is further recommended in future work.

This paper investigates the non-linear impacts of the agricultural, industrial, financial, and service sectors on environmental pollution in Malaysia during the 1980–2018 period. It employs the extended STIRPAT model and two indicators of environmental pollution (carbon dioxide emissions and ecological footprints). It uses the autoregressive distributed lag (ARDL) technique to estimate the parameters. Evidence from the study indicate that the agricultural, industrial, and service sectors have inverted U-shaped non-linear impacts on carbon dioxide emissions and ecological footprints, while the financial sector has a U-shaped non-linear relationship with carbon dioxide emissions and ecological footprint. These empirical outcomes are robust to diagnostic tests, structural breaks, and alternative estimation technique and proxies. The economic implication of this paper is that, at the early stage of sectoral growth, the pollution intensity of sectoral output increases, but after a certain turning point, a further increase in sectoral output will reduce environmental pollution. Precisely, environmental pollution will reduce if the agricultural, industrial, and service sectors exceed threshold levels of 11%, 44%, and 49% of GDP, respectively, while environmental pollution will be aggravated if financial sector exceeds a threshold level of 94%. Therefore, efforts to mitigate environmental pollution in Malaysia should integrate sectoral growth to attain sustainable development.