The alteration behavior of minerals and hazardous elements during simulated combustion (100–1200 °C) of a raw coal collected from a power plant were studied. Thermogravimetric analysis indicated that there were mainly four alteration stages during coal combustion. The transformation behavior of mineral phases of raw coal, which were detected by X-ray polycrystalline diffraction (XRD) technique, mainly relied on the combustion temperature. A series of changes were derived from the intensities of mineral (e.g. clays) diffraction peaks when temperature surpassed 600 °C. Mineral phases tended to be simple and collapsed to amorphous glass when temperature reached up to 1200 °C. The characteristics of functional groups for raw coal and high-temperature (1200 °C) ash studied by Fourier transform infrared spectroscopy (FTIR) were in accordance with the result obtained from XRD analysis. The volatilization ratios of Co, Cr, Ni and V increased consistently with the increase of combustion temperature, suggesting these elements were gradually released from the organic matter and inorganic minerals of coal.

Studying the characteristics of new particle formation (NPF) is important as it is generally recognized as a major contributor to particle pollution in urban environments. We investigated NPF events that occurred during a 1-year period in the urban environment of Brisbane, Australia, using a neutral cluster and air ion spectrometer (NAIS) which is able to monitor both neutral and charged particles and clusters down to a size of 0.8 nm. NPF events occurred on 41% of days, with the occurrence rate of 7% greater in the summer than in the winter. We derived the first diurnal event distribution of NPF events anywhere in the world and showed that the most probable starting time of an NPF event was near 08:30 a.m., being about an hour earlier in the winter than in the summer. During NPF days, 10% of particles were charged. The mean neutral and charged particle concentrations on NPF days were, respectively, 49% and 14% higher than those on non-event days. The mean formation rate of 2–3 nm particles during an NPF event was 20.8 cm⁻³ s⁻¹. The formation rate of negatively charged particles was about 10% higher than that of positively charged particles. The mean particle growth rate in the size range up to 20 nm was 6.2 nm h⁻¹. These results are compared and contrasted with corresponding values that have been derived with the scanning mobility particle sizer (SMPS) at the same location and with values that have been reported with the NAIS at other locations around the world. This is the first comprehensive study of the characteristics of NPF events over a significantly long period in Australia.

Microplastics have recently been detected in atmospheric fallout in Greater Paris. Due to their small size, they can be inhaled and may induce lesions in the respiratory system dependent on individual susceptibility and particle properties. Even though airborne microplastics are a new topic, several observational studies have reported the inhalation of plastic fibers and particles, especially in exposed workers, often coursing with dyspnea caused by airway and interstitial inflammatory responses. Even though environmental concentrations are low, susceptible individuals may be at risk of developing similar lesions. To better understand airborne microplastics risk to human health, this work summarizes current knowledge with the intention of developing awareness and future research in this area.

Given its wide distribution in the natural environment and global transport potential, mercury (Hg) is regarded as a ubiquitous pollutant. In this study, we carried out nation-wide sampling campaigns across China to investigate the distribution of Hg in agricultural soils. Concentrations of Hg in the soils collected in 2011 and 2016 ranged from 0.04 to 0.69 and 0.06–0.78 mg kg−1, respectively. Based on the data from 2016, the reserve of Hg in the surface arable soils (0–20 cm) in China was 4.1 × 104 metric tons and Chinese cultivated soils accounted for 63.4–364 metric tons of Hg released to the global atmosphere. The soil Hg concentrations were significantly higher than the reference background level, highlighting the impacts of anthropogenic activities. The vertical distribution pattern showed a clear enrichment at the surface and a decrease with depth of the soils. Comparison of calculated geo-accumulation indexes among individual provinces showed that Northwest China had higher levels of Hg contamination than other regions of China, likely due to long-term energy related combustions in the area. Soil Hg level showed strong positive correlations with organic matter contents of soil, as well as the mean annual precipitation and temperature of the sampling locations. The non-carcinogenic human health risks of soil Hg were below the threshold level, but the general risk to the ecosystem was considerable. The increases in Hg accumulation from 2011 to 2016 at provincial level were found to relate to coal combustion, power generation and per capita GDP. This examination of energy consumption and socioeconomic drivers for China's soil Hg reserve increase is critical for direct Hg control by guiding policy-making and targets of technology development in era of rapid economic growth.

More and more evidence indicates that persistent organic pollutants (POPs) are a risk factor for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Phenanthrene (Phe) is a kind of POP which existed extensively in the environment, but whose toxicity on mammals has so far received less focus. Subcutaneously injection of Phe (0.5, 5, 50 μg/kg) for 21 days induced significant NAFLD/NASH symptoms in new born rats. Exposure to environmental levels of Phe decreased body weight and liver-somatic index; impaired histology of liver; influenced the peroxisome proliferator-activated receptor gamma (PPARγ) signaling and lipid metabolism in liver; stimulated oxidative stress in the rats' liver; induced the variation of NFκB pathway and liver inflammatory response; and caused liver fibrosis via transforming growth factor β1 (tgfβ1). We speculated that the subcutaneously injected Phe was transferred to the liver through blood circulation, which may have induced the elevation of PPARγ directly or indirectly, leading to liver steatosis. Excess lipid, acting as the first hit, stimulated the second hit factors - oxidative stress, inflammatory response and lipid peroxidation, and finally resulted in steatohepatitis and liver fibrosis.

Due to their widespread occurrence in the aquatic environment, human and veterinary cephalosporin antibiotics have been studied as water pollutants. In order to characterize environmental risks of this compound class, this review evaluates relevant data about physicochemical properties, occurrence, ecotoxicity and degradation of cephalosporins. Although application of cephalosporins is rather low compared to other antibiotics and their environmental life-time is believed to be short (i.e. days), the available data is insufficient to draw conclusions on their environmental relevance. Few studies concerning the fate of cephalosporins in soil are available, while hydrolysis and photo-degradation are suggested as the main attenuation processes in the aquatic environment. Cephalosporins have been detected in different aqueous matrices in concentrations ranging from 0.30 ng L−1 to 0.03 mg L−1, with sewage and wastewater being the main matrices with positive findings. For wastewater treatment purposes, several technologies have been tested for the abatement of cephalosporins, including photolysis and adsorption. In most cases, the technology employed led to complete or significant removal (>95%) of parental drugs but few authors reported on cephalosporins' metabolites and transformation products. Furthermore, the present ecotoxicological data are insufficient for comprehensive ecological risk quotient calculations. Considering the total of 53 cephalosporins, effective values (EC, LC, NOAEC, NOAEL, etc.) are only available for around 30% of parental drugs and are very scarce for cyanobacteria, which is considered to be the most sensitive group of organisms to antibiotics. Furthermore, it has been demonstrated that cephalosporins' transformation products can be more toxic and more persistent than the parental drugs. Few investigations considering this possibility are available. Consequently, more effort on ecotoxicological data generation and verification of biological inactivation of cephalosporins-related products is needed. Likewise, the lack of natural depletion rates and knowledge gaps on mixture effects for cephalosporins’ degradation and toxicity have to be overcome.

Exposure to ambient air pollution has been linked with adverse health outcomes of the circulatory and nervous systems. Given that falls are closely related to circulatory and nervous health, we hypothesize that air pollution may adversely affect fall-related injury. We employed Wave 1 data from 36,662 participants aged ≥50 years in WHO's Study on Global AGEing and Adult Health in six low- and middle-income countries. Ambient annual concentration of PM2.5 was estimated using satellite data. A three-level logistic regression model was applied to examine the long-term association between ambient PM2.5 and the prevalence of fall-related injury, and associated disease burden, as well as the potential effect modification of consumption of fruit and vegetables. Ambient PM2.5 was found to be significantly associated with the risk of fall-related injury. Each 10 μg/m3 increase corresponded to 18% (OR = 1.18, 95% CI: 1.09, 1.28) increase in fall-related injury after adjusting for various covariates. The association was relatively stronger among participants with lower consumption of fruit (OR = 1.22, 95% CI: 1.12, 1.33) than higher consumption (OR = 1.06, 95% CI: 0.92, 1.23), and among those with lower vegetable consumption (OR = 1.18, 95% CI: 1.08, 1.28) than higher consumption (OR = 1.08, 95% CI: 0.91, 1.27). Our study suggests that ambient PM2.5 may be one risk factor for fall-related injury and that higher consumption of fruit and vegetables could alleviate this effect.

Excessive use of antibiotics in breeding industry leads to accumulation of antibiotic residuals and antibiotic resistance genes (ARGs) in environment from improperly treated livestock excrements. Four commonly used veterinary antibiotics including chlortetracycline (CTC), sulfamerazine (SMZ), enrofloxacin (ENR) and erythromycin (ERY) were monitored in the swine manure composting. Co-resistance and cross-resistance effects among relative ARGs, correlations between ARGs and bacterial community under multiple antibiotics residual during the composting were investigated in this research. With CTC addition up to 20 mg/kg, more than 99% of CTC removal was achieved after composting, and most of the other antibiotics can be thoroughly removed as well. The variations in ARGs during the composting were strongly correlated to the compositions of the microbial community, Bacteroides and Sporosarcina were main ARGs carriers in the thermophlic phase. Clostridium Ⅺ, Clostridium sensu stricto, and Pseudoxanthomonas, might spread ARGs in cooling and maturing stage. Most of the tested ARGs in swine manure can be effectively reduced through composting, thus makes the compost products safe for soil fertilization.

Diethyl phthalate (DEP) and dibutyl phthalate (DBP) are two typical small phthalate esters, extensively used in personal care and consumer products. Although previous studies have linked phthalate esters to several health issues, it is still unclear whether they can affects the early stages of embryonic development. In this study, we evaluated the early developmental neurotoxicity as well as the cytotoxicity of DEP and DBP, using mouse embryonic stem cells (mESCs). Our results showed that both DEP and DBP could decrease mESC viability in a dose-dependent manner. Moreover, while DBP could activate the caspase-3/7 enzymes and cause cell membrane damage as well as intracellular ROS accumulation, interestingly DEP treatment only showed stimulation of ROS production. In addition, DEP and DBP treatment at non-cytotoxic concentrations, abnormally altered the expression levels of several vitally important regulators of embryo development. For instance, neural ectoderm markers, such as Pax6, Nestin, Sox1 and Sox3, were significantly up-regulated upon DEP and DBP exposure. In conclusion, our work suggests a potential developmental toxicity of DEP and DBP on mammals, especially for neural ectoderm specification. Our findings help better understand the association between health problems and DEP/DBP exposure and most significantly remind us of the importance of additional health risk tests for these two largely used chemicals.

Perchlorate (ClO4−) contamination has been reported in ground and surface waters across North America. However, few studies have examined the effects of prolonged exposure to this thyroid hormone disrupting chemical, particularly at environmentally relevant concentrations in lower vertebrates, such as amphibians. The aim of this study was to examine the effects of a yearlong chronic exposure to ClO4− in adult male and female Western clawed frogs (Silurana tropicalis). Frogs were spawned and raised from fertilized embryo until sexual maturity in potassium perchlorate (KClO4)-treated water at different concentrations (0, 20, 53, and 107 μg/L). Developmental and reproductive indices – including adult morphology, androgen plasma levels, gonadal thyroid hormone- and sex steroid-related transcript levels, and sperm motility – were evaluated in male and female adult frogs. Female growth (e.g., body mass, snout-vent length, and hind limb length) was significantly reduced following chronic exposure to environmentally relevant concentrations of KClO4 resulting in females with morphometric indices similar to those of control males – indicating potential sex-specific sensitivities to KClO4. Changes to reproductive indices (i.e., plasma androgen levels, gonadal thyroid hormone- and sex steroid-related transcript levels, and sperm motility) were also observed in both sexes and suggest that KClO4 exposure may also have indirect secondary effects on the reproductive axes in male and female adult frogs. These effects were observed at concentrations at or below those reported in surface waters contaminated with ClO4− suggesting that this contaminant may have developmental and reproductive effects post-metamorphosis in natural amphibian populations.