The widely used Di-(2-ethylhexyl) phthalate (DEHP) has been reported to exhibit ubiquitous environmental and global health hazards. The bioaccumulation and environmental persistence of DEHP can cause serious health hazards in wildlife animals and human. However, DEHP-induced nephrotoxicity in bird is remained unknown. Thus, this study explored the related mechanism of DEHP nephrotoxicity in quail. For this purpose, quail were exposed with DEHP at doses of 0, 250, 500, and 1000 mg/kg body weight daily by gavage administration for 45 days. The results showed that DEHP exposure induced renal injury, oxidative stress, and endoplasmic reticulum (ER) degeneration. Low level DEHP (250 mg/kg) exposure inhibited Nrf2 signaling pathway and induced renal injury via oxidative stress and suppressed the unfolded protein response (UPR) signaling pathway and induced ER stress in the kidney. But surprisingly, high level DEHP (500 mg/kg and 1000 mg/kg) exposure activated Nrf2 and UPR signaling pathways and protected kidney, but they still couldn't resist the toxicity of DEHP. Our study demonstrated that DEHP-induced nephrotoxicity in quail was associated with activating Nrf2-mediated antioxidant defense response and UPR signaling pathway.

Accurate measuring n-octanol/water partition coefficients (log Kₒw) of perfluoroalkyl carboxylic acids (PFCAs) using experimental approach has been proven to be very difficult due to their special properties. The ionizable carboxyl groups in PFCAs make their log Kₒw dependent on pH. In this study, the log Kₒw values of neutral species of PFCAs (C₄≤ₙ≤₁₄) were measured based on reversed-phase high-performance liquid chromatography (RP-HPLC) with the mobile phase pH varying in the range of 1.09–5.00. The relationship between log Kₒw and retention times was established using some reference compounds (including agrochemicals, polycyclic aromatic hydrocarbons) with known log Kₒw values, and then validated with alkyl fatty acids, which have similar chemical structures as PFCAs. The apparent log Kₒw (i.e., log Dₒw) of the C₄–₁₄ PFCAs were calculated based on their retention times using the established model, and they displayed a negative linear relationship with the mobile phase pH in the range of 1.09–4.00. Consequently, the log Dₒw values were converted to the corresponding log Kₒw values (1.05–7.19) based on the relationship of log Dₒw = log Kₒw + pKₐ – pH. The log Kₒw increased with perfluorinated carbon chain length with a greater rate for C₄ to C₅ PFCAs than for C₅–₁₄ PFCAs.

Coastal areas provide important ecosystem services and affect local tourism. However, these areas are also sensitive to coastal erosion. The purpose of this study was to simulate a landscape plan scenario to improve the value of ecosystem services. The Shinduri coastal area in South Korea which has important natural resources, such as coastal sand dunes and coastal forests. To simulate landscape changes, this study was conducted using system dynamics. The study progressed in three stages: first, an analysis of the landscape change behavior model of Shinduri in its current state and an evaluation of the value of ecosystem services was conducted. Second, a simulation was carried out by applying a coastal erosion scenario. Third, a simulation of landscape change was run, and the value of ecosystem services was estimated, with regard to afforestation, thinning, weeding and coastal sand dune restoration plan scenarios. The results were as follows: in the absence of disturbances, current landscape change models are stable, and the value of ecosystem services, which was $859,259 in 2014, has increased over time. However, the value of ecosystem services decreased when subjected to a coastal erosion scenario. The evaluation of value of ecosystem services under afforestation, thinning, weeding and coastal sand dune plan scenarios revealed an optimal landscape plan that focuses on a coastal sand dune restoration plan suggesting restoration of these dunes at a rate of 27.05 ha per year. When the coastal sand dune restoration plan is applied, the value of ecosystem services increases to $ 895,474 by 2054. The coastal sand dune restoration plan should prioritize the protection of the coastal sand dune area as component of the restoration of coastal ecological resources in the area. These findings could contribute to the ecological management and improvement of coastal ecosystem services.

Toxocariasis is a neglected tropical disease of humans. Although many studies have indicated or shown that environmental contamination with Toxocara species eggs is a major risk factor for toxocariasis in humans, there has been no comprehensive analysis of published data or information. Here, we conducted the first systematic review and meta-analysis of current literature to assess the global prevalence of Toxocara eggs in public places (including beaches, parks and playgrounds). We conducted searches of the PubMed, Embase, Scopus and Science Direct databases for relevant studies published until 20 April 2018, and assessed the prevalence rates of Toxocara eggs in public places. We used the random effects model to calculate pooled prevalence estimates, with 95% confidence intervals (CIs), and analysed data in relation to WHO geographical regions. Subgroup analysis and meta-regressions regarding the geographical and environmental variables were also performed. Of 2384 publications identified, 109 studies that tested 42,797 soil samples in 40 countries were included in the meta-analysis. The pooled global prevalence of Toxocara eggs in public places was 21% (95% CI, 16–27%; 13,895/42,797). The estimated prevalence rates in the different WHO regions ranged from 13% to 35%: Western Pacific (35%; 95% CI, 15–58%), Africa (27%; 95% CI, 11–47%), South America (25%; 95% CI, 13–33%), South-East Asia (21%; 95% CI, 3–49%), Middle East and North Africa (18%; 95% CI, 11–24%), Europe (18%; 95% CI, 14–22%), and North and Central Americas (13%; 95% CI, 8–23%). A high prevalence was significantly associated with high geographical longitude (P = 0.04), low latitude (P = 0.02) and high relative environmental humidity (P = 0.04). This meta-analysis of data from published records indicates that public places are often heavily contaminated with eggs of Toxocara. This finding calls for measures to reduce the potential risk of infection and disease in humans.

Millimetre-sized fragments have been documented in many fish species, but their transfer through food webs is still poorly understood. Here we quantified and described plastic fragments in the digestive tracts of 43 Easter Island flying fish (Cheilopogon rapanouiensis) and 50 yellowfin tunas (Thunnus albacares) from coastal waters around Rapa Nui (Easter Island) in the South Pacific subtropical gyre, and of fish preyed upon by T. albacares. Overall, seven C. rapanouiensis (16%) individuals had ingested microplastics, most of which resembled the common planktonic prey of the fish. One microplastic was found in the gut of a fish ingested by a tuna, which indicates that trophic transfer may occur between tuna and prey. A single T. albacares (2%) had ingested five mesoplastics (15.2–26.3 mm) that were probably not mistaken for prey items, but rather accidentally ingested during foraging on fish prey. The absence of microplastics in T. albacares suggests that such small particles, if transferred from the prey, do not accumulate in the relatively large digestive tract of large predators. On the other hand, larger plastic items may accumulate in the gut of tunas, to which they may induce deleterious effects that still need to be examined. However, only a small portion of the fish had ingested mesoplastics. The results of this study suggest that microplastic contamination is not an immediate threat to large predatory fish, such as T. albacares, along the coast of Easter Island within the South Pacific subtropical gyre.

A limited but emerging body of evidence is suggestive for a beneficial association between contact with green spaces and glucose homeostasis in adults; however, such an evidence for children is scarce. We evaluated the association between time spent in green spaces and fasting blood glucose (FBG) levels and impaired fasting glucose (IFG, FBG≥110 mg/dL) in a population-based multicentric sample of 3844 Iranian schoolchildren aged 7–18 years (2015). Participants were instructed to report the average hours per week spent in green spaces separately during each season and in each type of green space (parks, woods/other natural green spaces, and private gardens/agricultural field) for a 12-month period preceding the interview. We developed linear and logistic mixed effects models with centre as random effect to evaluate the association of time spent in green spaces (separately for each type as well as all types together) with FBG and IFG, respectively, controlled for a wide range of covariates including household indicators of socioeconomic status. We observed inverse associations between time spent in green spaces, especially in natural green spaces, and FBG levels. Specifically, 1.83 h increase in the total time spent in green spaces was associated with −0.5 mg/dl (95% confidence intervals: −0.9, −0.1) change in FBG levels. We also observed reduced risk of IFG associated with time spent in green spaces; however, the association was statistically significant only for the time spent in natural green spaces. There were suggestions for stronger associations for those residing in urban areas and those from lower socioeconomic status groups; however, the interaction terms for socioeconomic status and urbanity were not statistically significant. Further longitudinal studies are required to replicate our findings in other settings with different climates and population susceptibilities.

Previous studies of long-term manure applications in paddy soil mostly focused on the effects on denitrification, occurrence of antibiotics and antibiotic resistance genes (ARGs) without considering the effects on anaerobic ammonium oxidation (anammox). Here, we investigated the potential rates of anammox and denitrification, occurrence of antibiotics and AGRs in response to three fertilization regimes (C, no fertilizer; N, mineral fertilizer; and NM, N plus pig manure) in six long-term paddy experiment sites across China. The potential rates of anammox (0.11–3.64 nmol N g−1 h−1) and denitrification (1.5–29.05 nmol N g−1 h−1) were correlated with the abundance of anammox genes (hzsB) and denitrification functional genes (narG, nirK, nirS and nosZ), respectively. The anammox and denitrification rates were affected by soil organic carbon (SOC) and significantly (p < 0.05) increased in NM treatments relative to those in N treatments. Although pig manure application increased antibiotic concentrations and abundance of ARGs compared with N treatments, the increased antibiotics did not directly affect the anammox and denitrification rates. Our results suggested that long-term pig manure application significantly increased antibiotic concentrations, abundance of ARGs, and rates of anammox and denitrification, and that the effects of pig manure-derived antibiotics on anammox and denitrification were marginal. This is the first report that investigates the effects of long-term pig manure application on anammox in paddy soils. More attention should be paid to the potential ecological risk of increased ARGs caused by pig manure application in paddy soils.

This study aimed to elucidate the origin of the widespread nicotine contamination of plant-derived commodities, by conducting field experiments with various herbs and spice plants. By scattering tobacco and cigarette butts on the field and subsequent nicotine analyses of the acceptor plants, we verified that the alkaloid is leached out into the soil and is taken up by the crop plants. This path of contamination pertains even when there is only one cigarette butt per square meter. Even such minor pollution results - at least in the case of basil and peppermint - in considerable high nicotine contaminations, which exceed the maximum residue level by more than 20-fold.The data reported here clearly outline the large practical relevance of this soil-borne contamination path and imply that unthoughtful disposal of cigarette butts in the field by farm workers may be the reason for the widespread occurrence of nicotine contamination in plant-derived commodities. Therefore, such misbehavior needs to be prevented using education and sensitization, and by including this issue into the guidelines of good agricultural practice.

The Arctic is a unique and fragile ecosystem that needs to be preserved and protected. Despite its remoteness, plastic pollution has been documented in this region. In the coming years, it is likely to worsen since, with climate changes and the opening of new shipping routes, the human presence is going to increase in the whole area. Here, we investigated the presence of microplastics (MPs) in sub-surface water and in two mid-trophic level Arctic fishes collected off Northeast Greenland: the demersal bigeye sculpin, Triglops nybelini, and the pelagic polar cod, Boreogadus saida. Plastics debris were found in the water samples at a concentration of 2.4 items/m³ ±0.8 SD which is higher than in most seas at lower latitudes. Both fish species had eaten MPs with different proportion among the species, 34% for T. nybelini (n = 71) and 18% for B. saida (n = 85). The significant difference in the occurrence of MPs between the two species is likely a consequence of their feeding behavior and habitat. Polyethylene was the main plastic polymer for water samples (41%, n = 17) and polyester (34%, n = 156) for fish samples as analyzed by Fourier Transformed Infrared (FT-IR) spectroscopy. Our data underscore that the Arctic regions are turning into a hotspot for plastic pollution, and this calls urgently for precautionary measures.

Identifying contamination sources of environmental media and revealing their changing trends over time is useful for regional contamination control and environmental improvements. Four sediment cores (S1−S4) were collected from the Shima River to determine lead (Pb) concentrations, geochemical fractions and isotopic compositions, as well as the geochronology of core S3. The results show that Pb concentrations decreased from the upper and middle reach sites (means: 57.6, 95.9, and 97.6 mg kg⁻¹, respectively) to the lower reach site (43.8 mg kg⁻¹), resulting in a minimal to moderate enrichment in the sediments; enrichment increased due to anthropogenic Pb inputs at the river middle reach site since the 1990s. Sediment Pb in the geochemical fractions followed a decreasing order of reducible (47.3%) > residual (37.8%) > oxidizable (11.2%) > acid-soluble fraction (3.68%), exhibiting high mobility, further verifying the anthropogenic inputs. A descending trend in the ²⁰⁶Pb/²⁰⁷Pb ratio of the top sediments was the result of anthropogenic activities. In the present study, coal combustion, which was the major anthropogenic Pb source determined by its isotopic composition, contributed significantly (means: 18.4–60.6%) to sediment Pb based on a three end-members model. Less of a contribution (0–10.6%) was derived from vehicle exhaust. The increasing trend in the coal contribution was in accordance with that of the coal consumption in the study area. These results suggest that Pb contamination resulting from coal combustion has grown to become a major environmental issue in the study area.