Having analysed research results, it is ensured that sustainable land use of US agricultural lands for the support to farmers to improve the efficiency of their major activities and adherence to the principles of soil protection and rational land use in farms. An analysis of the American experience allows us to make conclusions that the success of the process of improving land relations depends on the level of their scientific validity, the degree of balance of government regulation and the degree of coordination of participants’ interests in transformations and land market transactions. Land lease in the United States of America as one of the economic methods of land use regulation has been analysed in the article. It has been established that long-term lease relations are beneficial for both parties concerning soil improvement and pollution control in case of clear legislation. Having analysed foreign experience, the main measures of land use rationalization in the USA, which people can use in Ukraine, have been proposed. It is also possible to implement the US experience in actively controlling the ecological condition, intended use and other quality characteristics of agricultural land to improve regulation of land use in Ukraine. After analysing the measures for land protection in the United States, taking into account the considered and researched American experience of agricultural land use, ways to improve the existing system of use and protection of agricultural land in Ukraine are proposed.