Study on antiestrogenic effects of tamoxifen in immature rat uterus, 2; effects on synthesis of ribonucleic acid and protein
1986
Lee, H.J. (Kyongsang National Univ., Chinju (Korea R.). Dept. of Veterinary Medicine) | Jo, C.H. (Seoul National Univ., Seoul (Korea R.). Dept. of Veterinary Medicine) | Park, M.H. (Kyongsang National Univ., Chinju (Korea R.). Dept. of Veterinary Medicine)
The present study has been carried out to elucidate the antiestrogenic effects of tamoxifen on RNA and protein synthesis in uteri of immature rats. Immature female Sprague-Dawley rats were allocated into 4 groups and injected with 5 micro g of estradiol-17 beta, 50 micro g of tamoxifen, a combination of both, or vehicle only subcutaneously three times with an interval of 24 hrs respectively. The specific activities of 3H-uridine incorporation into uterine RNA and those of 3H-leucine incorporation into uterine protein were measured before and 1, 3, 6, 12, 24, 48 and 72 hrs after the above treatments
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