Effect of rifampicin and gentamicin on guinae pigs experimentally infected with Brucella melitensis
1989
Hosein, H.I. (Cairo Univ., Beni Suief (Egypt). Faculty of Veterinary Medicine) | Ghanem, F.M.
In this study 12 brucellosis free guinea-pigs were divided into 3 equal groups (A, B and C). All guinea-pigs were inoculated S/C with 1x105 cells of 2-days old Brucella melitensis biotype 3 in smooth form. Three weeks later blood serum of all animals reacted positively to the plate agglutination test (PAT). Four weeks post infection, group A animals were orally adminstered by 20 mg/Kg, B.W. rifampicin daily for 10 days, while group B animals, were injected 1/M by 20 mg/kg, B.W. gentamicin daily for 10 days. Animal in group C were kept as control. Six weeks post infection, blood was collected and all guinea-pigs were sacificed. The sera were tested by the PAT, Rivanol test and complement fixation test. Internal organs and lymph nodes were subjected to bacteriological tests
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