Synthesis and antifungal activity of 1,3-substituted-5-chloropyrazole-4-carboxylic acid oxime esters
1989
Kim, Y.W. | Park, C.H. | Choi, W.S. | Kwon, Y.C. (OCI Research Center, Inchon (Korea R.)) | Park, C.K. (Seoul National Univ., Suwon (Korea R.). Coll. of Agriculture)
A series of novel 1,3-substituted-5-chloropyrazole-4-carboxylic acid oxime esters was synthesized. Their chemical structures were elucidated on 1H, 13C-NMR and IR spectra. Fifteen such compounds were screened for their antifungal activity against R. solani, P. oryzae, B. cinerea, P. graminearum, P. capsici and G. cingulata. The results showed that pyrazole-oxime esters with electron withdrawing groups (III, XIII, XIV) had better biological activities than those with electron releasing groups
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