Preparation and characterization of monoclonal antibodies directed against glycoproteins of bovine leukaemia virus
1993
Orlik, O. | Ban, J. | Gieciova, E. | Altanerova, V. | Altaner, C. (Slovenska Akademia Vied, Bratislava (Slovak Republic). Ustav Molekularni Virologie)
Six monoclonal antibodies (MoAbs) directed against glycoproteins of bovine leukaemia virus (BLV) were prepared and characterized. Comparison of these MoAbs with anti-gp51 MoAbs of known epitope specificity by competition antibody binding assay allowed to distinguish two new conformational epitopes C1 and C2 on the molecule of gp51. Three newly prepared MoAbs were directed against known epitopes F, G and H, and their neutralizing activities of biological functions of gp51 were determined.
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