Excretion of orally and intravenously administered diacetoxyscirpenol in rats
1992
Yoshizawa, T. (Kagawa Univ., Miki (Japan). Faculty of Agriculture) | Sakamoto, T. | Swanson, S.P. | Buck, W.B.
The excretion and metabolism of diacetoxyscirpenol (DAS) following administration of single oral dose (2.8 mg/kg) or intravenous dose (0.20 mg/kg) was studied in male Wistar rats. DAS was found in urine nor feces by either route of administration. After oral administration, 78.8 % of the dose was recovered by day 5, and four metabolites including 15-monoacetoxyscirpenol (15-MAS), scirpentriol (SCP), 15-acetoxy-de-epoxyscirpenol (DRM-1) and de-epoxyscirpentriol (DRM-2) were found in both urine and feces. By contrast, only 35.3 % of the dose was recovered by day 2 after intravenous administraction, and the fate of the remaining 64.7 % was unknown. SCP was sole metabolite in urine, although both DRM-1 and DRM-2 were found in feces. The metabolic pathway of orally administered DAS in rats in proposed as follows: DAS is preferentially deacetylated at C-4 position to give 15-MAS, which is then metabolized to the final product, DRM-2 via SCP or via DRM-1
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