Transcriptional regulation of the beta-globin gene
1993
Popovic, Z. | Nikcevic, G. | Savkovic, S. | Marjanovic, J. | Pavlovic, S. (Institute of Molecular Genetics and Genetic Engineering, Belgrade (Yugoslavia))
We present recent data on the regulation of human, mouse, rat and chicken adult beta-globin gene transcription. Ubiquitous and erythroid specific cis-acting sequences found in promoter, core and 3' regulatory regions of the adult beta-globin genes are enumerated. Control regions bind multiple proteins, consisting of tissue-specific and general factors, whose composition changes during erythroid maturation. Binding of erythroid specific: GATA-1, NF-E2, NF-E4 and erythroid nonspecific: TFIID, CP1, Sp1, AP-1 and other proteins, is indicated. Finally, the proposed models for protein - DNA action resulting in transcription regulation are considered
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