Influence of Escherichia coli endotoxin induced fever on the pharmacokinetics and dosage regimen of oxytetracycline in cross-bred calves
1998
Singh, R.P. (Punjab Agric. Univ., Ludhiana (India). Coll. of Vet. Sci., Dep. of Vet. Med.) | Srivastava, A.K. | Sharma, S.K. (Punjab Agric. Univ., Ludhiana (India). Coll. of Vet. Sci., Dep. of Pharmacology and Toxicology) | Nauriyal, D.C. (Punjab Agric. Univ., Ludhiana (India). Coll. o f Vet. Sci., Dep. of Vet. Med.)
The pharmacokinetics and dosage regimen of oxytetracycline were determined in healthy and febrile cross-bred calves following its single intravenous administration (10 mg kg to the -1). Fever was induced by a single intravenous injection of E. coli endotoxin (1 microgram kg to the -1 i.v.). The elimination half life (t 1/2 beta) and the apparent volume of distribution [vd(area)] were slightly increased in febrile calves, as compared to healthy animals. The values of t 1/2 beta and Vd(area) were 3.22 plus or minus 0.20 h and 0.49 plus or minus 0.02 L. kg to the -1 in healthy calves and 4.06 plus or minus 0.32 h and 0.70 plus or minus 0.09 L kg to the -1, respectively, in febrile calves. An intravenous dosage regimen suitable for maintaining the minimum therapeutic plasma concentration of is more than or equal to 2 microgram/ml in febrile animals would be 10 mg kg to the -1 repeated at 12-h intervals
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