In vitro and in vivo cytogenetic analysis of the effects of cloprostenol on mammalian cells
1997
Djelic, N. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia). Department of Biology) | Andjelkovic, M. | Soldatovic, B. | Cvetkovic, D.
The aim of this study was to evaluate possible genotoxic effects of cloprostenol (Sinhrogal(R)), a synthetic analogue of prostaglandine F-2 alpha, which is used for synchronization of oestrus in domestic animals. The mutagenic potential of the test substance was investigated on human peripheral blood lymphocytes (in vitro) and bone marrow cells of intramuscularly treated BALB/c AnNCR male mice (in vivo), by monitoring numerical and structural chromosome aberrations, as well as determination of the mitotic index. There were no indications for a mutagenic potential of cloprostenol within the experimantal concentrations and doses applied in this investigation.
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