Effect of carboxylesterase inhibitor on resistance development to Paraoxon
1997
Milatovic, D. (Biotechnical Institute, Podgorica (Yugoslavia)) | Dettbarn, W.-D. (Vanderbilt University, Nashville, (USA))
This paper describes the importance of carboxylesterase in the detoxification mechanisms of Paraoxon. Preinhibition of carboxylesterase potentiated the toxicity and prevented the development of resistance normally seen with prolonged exposure to paraoxon. The results show that carboxylesterase of plasma, hydrolyzing alfa-NA and with high affinity to CBDP and paraoxon, is the critical enzyme involved in regulating sensitivity and resistance to paraoxon. Inhibitors of carboxylesterase are useful synergists potentiating organophosphorus insecticides. Their pre-application can effectively reduce the concentration of a given insecticide and prevent the development of resistance.
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