Study on the antifungal efficacy of juliflorine and benzene-insoluble alkaloid fraction of Prosopis juliflora
1997
Ahmad, A. | Ahmad, V. | Khalid, S.M. | Ansari, F.A. | Khan, K.A. (University of Karachi, Karachi 75270 (Pakistan). Dept. of Microbiology)
In vivo antidermatophytic activity of juliflorine and a benzene insoluble alkaloidal fraction obtained from Prosopis juliflora was tested against Trichophyton mentagraphytes infection produced in rabbits. Topical application of juliflorine in concentration of 0.5 percent, 1 percent, and 2.5 percent was found to heal 25 percent, 50 percent and 75 percent of dermatophytic lesions in three weeks, respectively. Benzene insoluble alkaloidal fraction was found comparatively more effective than juliflorine. The chemotherapeutic effects of these alkaloids were compared with Terbinafine which was found far more superior to these alkaloids against artificially produced dermatophytic infection
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