Metastases of a pheochromocytoma involving the central nervous system in a dog | Metastases d'un pheochromocytome entreprenant le systeme nerveux central chez un chien
2000
Poncelet, L. | Coppens, A.G. (Universite libre de Bruxelles (Belgium). Faculte de Medecine. Anatomie veterinaire) | Grauwels, M. | Dourov, N.
A seven-year-old female Cavalier King Charles presented a left oculomotor nerve palsy and a rapidly evolving flaccid paraplegia. On necropsy, a necrotic mass replaced the right adrenal gland almost completely, and tumours were observed in the liver, kidneys and lungs. A tumoural invasion of the right renal vein and the right trunk of the internal vertebral venous plexus at the caudal lumbar level were disclosed. Two tumours were present on the dura-matter at the level of the left cerebral hemisphere and a subarchnoidal tumour compressed the left oculomotor nerve. All tumoural locations exhibited the same histological features. Argyrophilic granules were demonstrated in the tumoural cell cytoplasm and immunohistochemical staining for neurone specific enolase was positive. This malignant neurosecretory tumour was classified as a phaeochromocytoma on the basis of the microscopic and biochemical features and the involvement of one adrenal gland. The concurrent tumoural invasion of a renal vein and of the vertebral venous plexus has not yet been described in the dog and suggests that a retrograde venous spread through the vertebral plexus may have contributed to the central nervous system involvement in this dog.
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