Physiological role of L-ascorbic acid in rats exposed to cigarette smoke
Kurata, T. (Ochanomizu Univ., Tokyo (Japan). Inst. of Environmental Science for Human Life) | Suzuki, E. | Hayashi, M. | Kaminao, M.
This study clarifies the effect of exposure to cigarette smoke on L-ascorbic acid (AsA) metabolism and on the activities of drug-metabolizing enzymes. Male Wistar rats were used. The test rats (group T) were exposed to side-stream smoke from cigarette for 2 h every day for 25 days. During the experimental period, the excreted amount of Asa in the urine from group T was higher than that from the control group (group C). At the end of the experimental period, the AsA content of the plasma and tissues, the liver cytochrome P-450 content and the activities of drugmetabolising enzymes in group T were each higher than those in group C
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