Analgesic activity of leaf extract of Coldenia procumbens, Linn.
2001
Senthamarai, R. | Kavimani, S. | Jaykar, B. | Uvarani, M. (Periyar Coll. of Pharmaceutical Sciences for Girls, Tamilnadu (India))
Coldenia procumbens, Linn. (Boraginaceae) has been used traditionally for the treatment of rheumatic swellings, fever, headache and piles. The benzene, chloroform, acetone and alcoholic extracts of the leaves of C. procumbens were screened for analgesic activity using Tail Clip and Hot Plate Methods. In both the methods, all the extracts (200 mg/kg) exhibited significant analgesic activity when compared with standard drug Morphine sulphate (5 mg/kg). The basal reaction time after the benzene and alcoholic extract treatment was increased to near Morphine sulphate. The possible mechanism may be due to involvement of opioid receptors and by enhancement of threshold to painful stimuli.
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Эту запись предоставил National Agricultural Research Centre