Molecular mechanisms of animal and plant ageing ensuing from oxidative stress
2001
Srbova, M. | Wilhelm, J. (Karlova Univ., Prague (Czech Republic)) | Wilhelmova, N.
Reactive oxygen species are precursors of free radical intermediates and participate in the development of various pathological states and also play a role in the process of ageing. They originate in vivo from different enzymic or non-enzymic reactions. Production of reactive oxygen species results in membrane lipid peroxidation, protein oxidation, modification of nucleotides, and other subsequent reactions. Deterioration of protective antioxidant mechanisms results in damage to an organism at all organizational levels (subcellular, cellular, organ) and is revealed as degenerative changes observed during ageing. There are principally two periods of ageing. The first, stochastic, is associated with advancing loss of physiological functions. The terminal stage of ageing, senescence, is genetically controlled to different extent in plants and animals. There are great differences at the organ level, plants having the ability to survive senescence of their organs and recycle the material for the purposes of the whole organism.
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