The influence of immunization with porcine zona pellucida upon bitch ovaries
2001
Mircu, C. (Faculty of Veterinary Medicine, Timisoara(Romania)) | Cernescu, H. | Ghize, Gh. | Bonca, Gh. | Ardelean, V. | Igna, V.
The xeno-immunization potentials of zona pellucida and their effects on reproductive functions are supported by numerous experimental data. The variations in immune response depend on the immunogenic structure (fractions of purified or non purified zona pellucida) affecting both ovarian structure and function. In the present study, we have investigated the effect exerted by a different number of immunizations with porcine zona pellucida on canine oocyte capacity to resume and undergo meiosis, and also on the histological structure of ovaries in the immunized bitches. Immunization and boosters were performed with equal doses of porcine zona pellucida together with oocytes (one administration in group B, two in group C and three in group D). Following ovariectomy, oocyte development in vitro was estimated and histological sections examined for the presence of histo-pathological changes. The increasing number of boosters negatively influenced oocyte capacity for resuming and undergoing meiosis. Furthermore, alterations of ovarian structure were more prominent and were manifested by the absence of normal ovarian follicles and oocyte loss.
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