Pathomorphological alterations and reparatory processes in the kidneys of broilers treated with ochratoxin A
2001
Nedeljkovic-Trailovic, J. | Sinovec, S. | Sinovec, Z. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia))
A 42-day long trial was performed on a total of 48 Hybro broilers divided into four groups. After a 14 days pre-experimental period, the experimental groups were offered feed contaminated with 0.5, 1.0 or 1.5 ppm ochratoxin A, respectively. After that period all groups were normally fed a mixture without added OTA until the end of the trial. Kidney samples were taken after the period of using contaminated feed, as well as after withdrawal the contaminated feed and a 3 week resting period. Proximal tubules were predominantly affected, while glomerules were chiefly preserved. The cytoplasm of tubulocytes was microgranulated and the nuclei were masked. Vacuolization was noticed in a certain number of altered cells. Foci of acute tubular necrosis were noticed in a few tubules. In some cases weak hemorrhage could be seen in affected areas. In the kidney samples of the group offered contaminated feed followed by a 3 week resting period morphological alterations were expressed in the form of intracellular edema. Epithelial cells of proximal tubules were enlarged with opaque cytoplasm, which caused tubule lumen stenosis. Apoptotic bodies could be noticed between some tubulocytes. The obtained results suggest that kidney alterations induced by OTA could be restored only to a certain extent as well as that minimum three week resting period is necessary for this process.
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