Toxicity study of 8-propionate-2-Beta (D+) glucosyl-9, 10-pyranopyridine isolated from Streptomyces species on long Evan's rats

Barman, R.K.; Sathi, Z.S. . Dept. of Pharmacy; Habib, M.A.; Chowdhury, M.A.U.; Biswas, M.H.U.; Gafur, M.A.; Rahman, M.A.A.

Toxicity study of 8-propionate-2-Beta (D+) glucosyl-9, 10-pyranopyridine isolated from Streptomyces species on long Evan's rats

2002

The subacute toxicity studies of 8-propionato-2-Bita (D+) glucosyl- 9,10- pyranopyridine (R-1), isolated from the Streptomyces species was carried out in Long Evanþs rats. The compound was administered at a dose of 300 mug/rat/day for 14 consecutive days. The gross general observations such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of the liver, kidney, heart and lungs were investigated both in control and experimental rats. The body weights of the rats were slightly increased. The change of hematological and biochemical parameters were statistically non-significant. No abnormalities were detected in the histopathology of the liver, kidneys, heart and lungs in the experimental group of rats as compared with control group of rats.

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