Ultra-morphological alteration in pregnant rat liver induced by Pyralene 3000
2001
Vrecl, M. | Fazarinc, G. | Bavdek, S.V. | Pogacnik, A. (Ljubljana Univ. (Slovenia). Veterinary Fac.) | Jan, J. (Ljubljana Univ. (Slovenia). Medical Fac.)
This study examined the ultrastructural changes in pregnant rat liver of animals administered with commercial polychlorinated biphenyls (PCBs). Pyralene 3000 (total 120 mg/kg body weight) was given to Wistar rats by intraperitoneal injection on days 7 and 9 of pregnancy. Control animals were injected with vehicle only. On day 12 after the second administration the rats were sacrificed and selected samples (liver, blood and adipose tissue) were collected and processed for further analyses [high resolution gas chromatography (HRGC) and transmission electron microscopy]. HRGC analysis showed a selective enrichment of penta- (Nos. 105, 110, and 118) and hexa-chlorobiphenyl (No. 138) congeners and depletion of tri- and tetrachloro congeners relative to the original PCB administered in adipose tissue of treated animals. Electron micrographs of the liver from treated animals revealed that the hepatocyte alteration comprised mainly augmentation of smooth endoplasmic reticulum as well as mitochondrial abnormalities, increased peroxisome numbers and reduced glycogen content. It is plausible to suggest that the observed alterations are mainly induced by enriched coplanar mono-ortho PCB congeners Nos.105 and 118.
Показать больше [+] Меньше [-]Ключевые слова АГРОВОК
Библиографическая информация
Эту запись предоставил University of Ljubljana