Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review
Bartos, P.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic))E-mail:bartos@vri.cz | Falkinham, J.O.(Virginia Polytechnic Inst. and State Univ., Blacksburg (USA). Dept. of Biology) | Pavlik, I.(Vyzkumny Ustav Veterinarniho Lekarstvi, Brno (Czech Republic))
Mycobacteria are intracellular bacterial parasites of macrophages where they can survive and proliferate for long periods of time. Because mycobacterial survival in macrophages is required for virulence, a great deal of effort has been focused on identifying the genetic and physiologic determinants of intracellular survival and growth. A number of factors, among them catalases, peroxidases, and superoxide dismutase have been suggested as agents permitting mycobacteria to overcome the intracellular defences of macrophages. The characteristic features of mycobacterial catalase/peroxidases and superoxide dismutase, their distribution within the genus Mycobacterium, and their mutual interactions in the inactivation of toxic oxygen products are reviewed. The role of mycobacterial catalase-peroxidase and superoxide dismutase in virulence are highlighted.
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