Isolation of echinocystic acid-3-O-sulfate, a new triterpene, from Tetrapleura tetraptera, and evaluation of the mutagenic potential of molluscicidal extracts and isolates.
1993
Ngassapa, O | Beecher, C. W. W. | Pezzuto, J. M. | Farnsworth, N. R. | Henderson, T. O. | Boye, G. L.
The stem bark and fruits of T. tetraptera are widely used in ethnomedicine. A known triterpene glycoside, 3-O-{beta-D-glucopyranosyl-1(1"-6')-2'-acetamido-2'-deoxy-beta-D-glucopyranosyl}olean-12-en-28-oic acid, and a new sulphated triterpene, echinocystic acid-3-O-sodium sulphate, were isolated from extracts of the stem bark of T. tetraptera (collected from Mampong-Akwapim, Ghana). Their structures were elucidated from spectral and chemical analyses. The triterpene glycoside was 100% lethal to Biomphalaria glabrata at 20 p.p.m. In a forward mutation assay utilizing Salmonella typhimurium strain TM677, the stem bark extracts were mutagenic and bactericidal in the absence of a metabolic activating system (S-9); the MeOH extract of the fruit exhibited weak mutagenic and antibacterial activity in the presence of S-9. The stem bark isolates, which also included aridanin and 3-O-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)echinocystic acid (previously reported from the fruits), were not mutagenic, either with or without metabolic activation.
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Эту запись предоставил Forestry Research Institute of Ghana