Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men
Toba, Y. (Snow Brand Milk Products Co. Ltd., Kawagoe, Saitama (Japan). Technical Research Inst.) | Takada, Y. | Matsuoka, Y. | Morita, Y. | Motouri, M. | Hirai, T. | Suguri, T. | Aoe, S. | Kawakami, H. | Kumegawa, M. | Takeuchi, A. | Itabashi, A.
Milk contains several components effective for bone health. In the previous in vitro and in vivo studies, we have shown that milk whey protein, especially its basic protein fraction (milk basic protein [MBP]), promoted bone formation and suppressed bone resorption. Tbis present study examines the effect of MBP on the biochemical markers of bone metabolism in healthy adult men. Experimental beverages coutaining MBP (300 mg of MBP a day) were given to 30 normal healthy adult men for 16 days. The serum osteocalcin concentration had increased significantly after 16 days of ingesting the experimental beverage containing MBP. Urinary cross-linked N-teleopeptides of type-1 collagen (NTx) excretion had decreased significantly after 16 days of ingesting MBP. The urinary NTx excretion was related to the serum osteocalcin concentration after 16 days of ingestion. These results suggest that MBP promoted bone formation and suppressed bone resorption, while maintaining the balance of bone remodeling.
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