Isolation of antifouling substances from the palauan sponge Protophlitaspongia aga
2001
Hattori, T. (Marine Biotechnology Inst., Shimizu, Shizuoka (Japan). Shimizu Lab.) | Matsuo, S. | Adachi, K. | Shizuri, Y.
Fouling organisms cause serious problems by settling on ships' hulls, and other marine infrastructures. Organotin compounds have been developed as effective antifoulants. However, environmental problems are associated with these compounds. It is necessary to find antifouling substances that exhibit a lower toxicity than those substances currently used. A new pyrimidine derivative, 3, 4, 5, 6 -tetrahydro-6-hydroxymethyl- 3, 6 -dimethyl- 4-pyrimidinecarboxylic acid, (compound 1) and zooanemonin (compound 2) were isolated from the marine sponge Protophli taspongia aga as antifouling substances against the barnacle Balanus amphitrite. We also found that cc-nicotinamide ribose (compound 3) inhibited germination and the attachment of Ulva spores.
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