The Anti- and Pro-oxidative Effects of Orally Administered Flavonoids in Normal Rats
2004
Choi, E.J. (National Cancer Center, Iisan, Republic of Korea) | Chee, K.M. (Korea University, Seoul, Republic of Korea) | Choi, M.Y. (Sanji University, Wonju, Republic of Korea)
The present study was designed to investigate the effects of genistein, daidzein, and quercetin on the antioxidative systems of normal rats. Male Sprague-Dawley rats were divided randomly into seven groups and treated with flavonoids at either 2 or 20 ㎎/day or through vehicle for four weeks. Lipid peroxidation in the liver was inhibited significantly following administration of quercetin. Genistein and daidzein did not have significant effects except in rats treated with 20㎎ daidzein/day. Genistein and daidzein treatment did not affect the content of α-tocopherol in the serum and liver, while quercetin caused a slight increase.
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