Effect of Green Tea Catechin on Acute Hepatotoxicity in Rats
2004
Yuk, D.Y. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, M.Y. (Cheongju University, Cheongju, Republic of Korea) | Yun, Y.P. (Chungbuk National University, Cheongju, Republic of Korea)
Green Tea Catechin (GTC) is known to have a wide variety of pharmacological activities. In the present study, the effects of GTC on acute hepatotoxicity induced by carbon tetrachloride (CCl₄) and galactosamine were examined in rats. Two doses (50 or 100 mg/kg) of GTC were administered to rats orally for 3 days before or after the induction of hepatotoxicity. A hepatotoxicity was induced by the intraperitoneal injection of the CCl₄(0.5 ml/kg) or galactosamine (400 mg/kg).
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