Various Fatty Acids Induce Cell Damages Differently in CYP2E1-transduced Hep G2 Cells, E47 Cells, Compared to C34 Cells
2006
Lee, M.S. (Sungshin Women's University, Seoul, Republic of Korea), E-mail: sungshin,ac.kr | Bae, M.A. (Korea Research Institute of Chemical Technology, Daejon, Republic of Korea)
The differential effects of various fatty acids such as n-3 and n-6 types or degrees of unsaturation on the CYP2E1 induction and the production of lipid peroxidation (LPO) were investigated. The CYP2E1-transduced human hepatoma HepG2 cells (E47) were cultured in RPMI 1640 media containing different concentrations of various fatty acids up to 48h incubation compared to C34 cells and CYP2E1-null cells. Treated fatty acids were linoleic acid (LA:n-6, C18:2), arachidonic acid (AA:n-6, C20:4) and docosahexaenoic acid (DHA:n-3, C22:6).
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