Inhibition of L-DOPA-Induced Increase in Dopamine Content by (1R,9S)-β-Hydrastine Hydrochloride in PC12 cells
2004
Yin, Shou Yu (Yanbian University, Yanji, Jilin, P.R. China) | Lee, J.J. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, Y.M. (Chungbuk National University, Cheongju, Republic of Korea) | Jin, Chun Mei (Chungbuk National University, Cheongju, Republic of Korea) | Yang, Y.J. (Chungbuk National University, Cheongju, Republic of Korea) | Kang, M.H. (Chungbuk National University, Cheongju, Republic of Korea) | Lee, M.K. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: [email protected]
The effects of BHSH on L-DOPA-induced increase in dopamine content in PC 12 cells were investigated. L-DOPA treatment at 20 or 50 μM increased dopamine content after both 24 and 48 h of incubation in PC12 cells. However, the co-treatments of BHSH (10-50 μM) with L-DOPA (20 or 50 μM) significantly inhibited the increase of dopamine content induced by L-DOPA. BHSH treatment at 10-50 μM significantly inhibited basal aromatic L-amino acid decarboxylase (AADC) activity in a concentration-dependent manner at 15 min, and then AADC activity was rapidly recovered to the control level at about 2 h.
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