Hepatotoxicity in treatment of canine dermatophytosis with ketoconazole
2005
Bae, S.S. (Gyeongsang National University, Jinju, Republic of Korea) | Kim, C.H. (Gyeongsangnam-do Livestock Promotion Institute, Jinju, Republic of Korea) | Kim, T.Y. (Ministry of Agriculture and Forestry, Kwacheon, Republic of Korea) | Kang, C.B. (Gyeongsang National University, Jinju, Republic of Korea), E-mail: cbkang@gsnu.ac.kr
The purpose of this study is to compare hepatotoxicity of each treatment for dermatophytosis; one is the administration of the ketoconazole only and the other, ketoconazole with diphenyl-dimeththyl-dicarboxylate. Have chosen the range of 14-24 months of healthy dogs divided by two groups (group 1 and group 2) for the experiment of which test proved positive in dermatophytosis diagnosis and showed normal reaction in terms of physical examination, blood chemistry and especially of liver function. Group 1 was administrated ketoconazole orally at 10 mg/kg/day and of same dose of ketoconazole with diphenyl-dimethyl-dicarboxylate for group 2.
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