Mechanism of gemcitabine-induced apoptosis
2005
Seol, J.W. (Chonbuk National University, Jeonju, Republic of Korea) | Lee, Y.J. (Chonbuk National University, Jeonju, Republic of Korea) | Kang, D.W. (Chonbuk National University, Jeonju, Republic of Korea) | Kang, H.S. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, N.S. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, I.S. (Chonbuk National University, Jeonju, Republic of Korea) | Pak, S.Y. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: sypark@chonbuk.ac.kr
The nucleoside analogue gemcitabine (2', 2-difluorideoxycytide) is potential against a wide variety of solid tumors and considered to be one of the most active drugs in the treatment of non-small cell lung cancer (NSCLC). In this study, we investigated the signals of gemcitabine-induced apoptosis, especially in point of caspase pathway in A549. We exposed A549 cells to gemcitabine for dose/time dependent manner and the results showed that gemcitabine induced apoptotic cell death in a time/dose-dependent manner. We also treated to gemcitabine and Z-VAD-fmk as a pan-caspase inhibitor for 24 hours.
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