Expression of caveolin-3 as positive intracellular signaling regulator on the development of hypertrophy in cardiac tissues
2005
Kim, J.H. (Gyeongsang National University, Jinju, Republic of Korea) | Han, J. (Inje University, Busan, Republic of Korea) | Kim, Y.K. (Inje University, Gimhae, Republic of Korea) | Hong, Y.G. (Inje University, Busan, Republic of Korea), E-mail: yonghong@inje.ac.kr | Yang, Y.A. (Inje University, Gimhae, Republic of Korea)
We have examined distribution and expression of caveolin-3 (cav-3), one of three caveolin isoforms from 16-wks-old spontaneously hypertensive rats (SHR) compared with age-matched control wistar-kyoto (WKY) rats. The expression of cav-3 was increased, whereas expression of PKB/Akt and calcineurin (Cn) was not changed in cardiac tissues of SHR compared to WKY rats. Interestingly, expression of cav-3, PKB/Akt and Cn were decreased in plasma membrane fraction in SHR compared to WKY rats. In H9c2 cardiomyoblast cells treated with phenylephrine (50 μM, 48hr) or isoproterenol (10 μM, 48hr), the expression of cav-3 was markedly enhanced compared to nontreated cells.
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