Corn silk induced cyclooxygenase-2 in murine macrophages
Kim, K.A.(University of Ulsan (Korea R.)) | Shin, H.H. | Choi, S.K. | Choi, H.S.
Stimulation of murine macrophages with corn silk induced cyclooxygenase (COX)-2 with secretion of PGEsub(2). Expression of COX-2 was inhibited by pyrolidine dithiocarbamate (PDTC), and increased DNA binding by nuclear factor kappa B (NF-kappaB), indicating that COX-2 induction proceeds also via the NF-kappaB signaling pathway. A specific inhibitor of COX-2 decreased the expression level of inducible nitric oxide synthase (iNOS) stimulated by corn silk. PGEsub(2) elevated the expression level of iNOS, probably via EP2 and EP4 receptors on the surface of the macrophages.
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